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- W2489741213 abstract "Hydrocobalamin is a cobalt-based direct cyanide chelating antidote. Of all the cyanide antidotes in current clinical use, hydroxocobalamin is at least as efficacious as the others and has the most favorable safety profile. Hydroxocobalamin is more rapidly acting than sodium thiosulfate, does not produce methemoglobinemia as do some cyanide antidotes, and is not associated with potential life-threatening adverse effects especially when administered in the absence of cyanide poisoning, as does dicobalt-EDTA (Kelocyanor ). Studies of hydroxocobalamin in a number of animal species have shown its efficacy. Hydroxocobalamin is administered intravenously at a dose of 5 grams over 15–20 minutes, although in emergency situations it can be given more rapidly. Hydroxocobalamin has an intense reddish-brown color and a peak light absorption at 352 and 526 nanometers. Hydroxocobalamin does not induce methemoglobinemia as do the nitrite cyanide antidotes and 4-DMAP." @default.
- W2489741213 created "2016-08-23" @default.
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- W2489741213 date "2015-11-04" @default.
- W2489741213 modified "2023-10-12" @default.
- W2489741213 title "Cyanide antidotes in current clinical use: hydroxocobalamin" @default.
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- W2489741213 doi "https://doi.org/10.1002/9781118628966.ch25" @default.
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