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- W248976260 abstract "Previous studies showed that after high doses of radiation the lipid content of the Sertoli cells becomes greatly increased. In the presert experiments rats were irradiated and small fragments of their testes examined cytochemically and the remainder homogenized in a lipid solvent. Only a small amount of iipid was seen in interstitial tissue while a large amount was present in Sertoli cells. The lipid extracted from irradiated testes gave a positive response to tests for progesterone or its metaboiites. The hormonal activity is attributed to the lipid of the Sertoli cells. ln rats treated with estrogenic hormone, by means of both light and eiectron microscopy a marked increase in Sertoli cell lipid was demonstrated whereas the interstitial lipid remains at a very low level. Lipid extracted from the testes of estrogen-treated rats also gave a positive test for progesterone. The accumuiation of iarge amounts of lipid in irradiated and estrogen-treated rats was correlated with the lack of spermatogenesis in the 1st group and its inhibition in the latter. Hence it is concluded that the Sertoli cells synthesize a steroid hormone, the Sertoli cell hormone (SCH), which is normally utilized during spermatogenesis. Estrogenic hormone causes necrosis of primary spermatocytes during meioticmore » prophase. When follicle-stimulating hormone (FSH) is applied the lipid content of the Sertoli cells is reduced to normal levels and spermatogenesis restored. Thus FSH is necessary either for the final stages of synthesis or secretion or both of SCH. (H.H.D.)« less" @default.
- W248976260 created "2016-06-24" @default.
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- W248976260 date "1961-04-01" @default.
- W248976260 modified "2023-09-24" @default.
- W248976260 title "THE USE OF IONIZING RADIATION AND ESTROGEN TREATMENT IN THE DETECTION OF HORMONE SYNTHESIS BY THE SERTOLI CELLS" @default.
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