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• W2489774512 endingPage "e0158643" @default.
• W2489774512 startingPage "e0158643" @default.
• W2489774512 abstract "Food allergy is a serious problem for infants and young children. Induction of antigen-specific oral tolerance is one therapeutic strategy. Enhancement of oral tolerance induction by diet is a promising strategy to prevent food allergy in infants. Thus, in this study, we evaluate the effect of probiotic Lactobacillus gasseri OLL2809 (LG2809) on oral tolerance induction in a mouse model. The degree of oral tolerance induction was evaluated by measuring the proliferation and level of IL-2 production of splenic CD4+ T cells from DO11.10 mice fed ovalbumin (OVA) alone or OVA with LG2809. Oral administration of LG2809 significantly decreased the rate of proliferation and IL-2 production by CD4+ T cells from OVA-fed mice. LG2809 increased a ratio of CD4+ T-cell population, producing high levels of IL-10 and having strong suppressive activity. Moreover, LG2809 increased a ratio of plasmacytoid dendritic cells (pDCs) among the lamina propria (LP) in small intestine. When used as antigen presenting cells to naïve CD4+ T cells from DO11.10 mice, LP cells from BALB/c mice fed LG2809 induced higher IL-10 production and stronger suppressive activity than those from non-treated mice. These results suggest that oral administration of LG2809 increases the population of pDCs in the LP, resulting in the enhancement of oral tolerance induction by increasing the ratio of effector regulatory T cells. LG2809 could, therefore, act as a potent immunomodulator to prevent food allergies by promoting oral tolerance." @default.
• W2489774512 created "2016-08-23" @default.
• W2489774512 creator A5001049289 @default.
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• W2489774512 date "2016-07-29" @default.
• W2489774512 modified "2023-10-12" @default.
• W2489774512 title "Enhancement of Oral Tolerance Induction in DO11.10 Mice by Lactobacillus gasseri OLL2809 via Increase of Effector Regulatory T Cells" @default.
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• W2489774512 doi "https://doi.org/10.1371/journal.pone.0158643" @default.
• W2489774512 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4966961" @default.
• W2489774512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27472281" @default.
• W2489774512 hasPublicationYear "2016" @default.
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