FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2489805306> ?p ?o ?g. }

• W2489805306 endingPage "108" @default.
• W2489805306 startingPage "57" @default.
• W2489805306 abstract "Publisher Summary This chapter discusses the strategies and approaches used to develop understanding of complex signaling networks. It focuses on two layers as templates: transcriptional regulatory processes as an ultimate controller of cell function, and protein kinase pathways as a crucial upstream “information processing” governor located downstream of environmental stimuli. Earlier investigations on binary enzyme–substrates interactions have been superseded by studies of signaling networks associated with complex and diffuse processes often resulting in subtle biological consequences. In building such network maps for higher mammalian systems pertinent to medicine, protein–protein interactions and generalized enzyme–substrate databases have formed one foundation, and transcriptional regulatory networks have formed the second foundation. The challenges in making use of these datasets lie in uncovering hierarchy of effect, integration of heterogeneous data, and the incorporation of dynamical, time-dependent data to improve the predictive value of the models. A primary control point in the regulation of differential gene expression is transcription. The basis of mapping transcriptional regulatory networks began with the development of expression arrays. Transcription is controlled by a direct and specific interaction between a transcription factor and many discrete locations within the genome, guided by a DNA sequence recognition motif. Phosphorylation of proteins by protein kinases is regulated at several levels. First, the kinase and potential ligand must be colocalized in the cell. Second, the kinase activity is generally increased when the kinase is in an active structural conformation. Phosphoproteins are of tremendous importance in eukaryotic cellular signaling and regulation." @default.
• W2489805306 created "2016-08-23" @default.
• W2489805306 creator A5005499510 @default.
• W2489805306 creator A5005961131 @default.
• W2489805306 creator A5012603340 @default.
• W2489805306 creator A5017001073 @default.
• W2489805306 creator A5021671441 @default.
• W2489805306 creator A5060106170 @default.
• W2489805306 date "2010-01-01" @default.
• W2489805306 modified "2023-09-25" @default.
• W2489805306 title "Cellular Regulatory Networks" @default.
• W2489805306 cites W1486257535 @default.
• W2489805306 cites W1493799579 @default.
• W2489805306 cites W1502432690 @default.
• W2489805306 cites W1504478980 @default.
• W2489805306 cites W1512092650 @default.
• W2489805306 cites W1514077182 @default.
• W2489805306 cites W1521881285 @default.
• W2489805306 cites W1554180547 @default.
• W2489805306 cites W1570204439 @default.
• W2489805306 cites W1591760396 @default.
• W2489805306 cites W1595990218 @default.
• W2489805306 cites W1599207601 @default.
• W2489805306 cites W1607267312 @default.
• W2489805306 cites W1643500256 @default.
• W2489805306 cites W1647597862 @default.
• W2489805306 cites W1669374546 @default.
• W2489805306 cites W1784857457 @default.
• W2489805306 cites W1883761849 @default.
• W2489805306 cites W1958512987 @default.
• W2489805306 cites W1963674435 @default.
• W2489805306 cites W1964861583 @default.
• W2489805306 cites W1968528605 @default.
• W2489805306 cites W1969480944 @default.
• W2489805306 cites W1970970926 @default.
• W2489805306 cites W1976173969 @default.
• W2489805306 cites W1976564639 @default.
• W2489805306 cites W1976662277 @default.
• W2489805306 cites W1979028385 @default.
• W2489805306 cites W1979833590 @default.
• W2489805306 cites W1981552687 @default.
• W2489805306 cites W1982481323 @default.
• W2489805306 cites W1982499456 @default.
• W2489805306 cites W1982555128 @default.
• W2489805306 cites W1983512144 @default.
• W2489805306 cites W1984563220 @default.
• W2489805306 cites W1984871500 @default.
• W2489805306 cites W1985184433 @default.
• W2489805306 cites W1985911638 @default.
• W2489805306 cites W1986570146 @default.
• W2489805306 cites W1987169965 @default.
• W2489805306 cites W1988294855 @default.
• W2489805306 cites W1989053944 @default.
• W2489805306 cites W1989076816 @default.
• W2489805306 cites W1991149014 @default.
• W2489805306 cites W1991185690 @default.
• W2489805306 cites W1992901862 @default.
• W2489805306 cites W1992945955 @default.
• W2489805306 cites W1993351732 @default.
• W2489805306 cites W1993564826 @default.
• W2489805306 cites W1994652412 @default.
• W2489805306 cites W1994803330 @default.
• W2489805306 cites W1997344583 @default.
• W2489805306 cites W1997767982 @default.
• W2489805306 cites W1998415342 @default.
• W2489805306 cites W1998487776 @default.
• W2489805306 cites W2001620484 @default.
• W2489805306 cites W2003931365 @default.
• W2489805306 cites W2003952411 @default.
• W2489805306 cites W2004677335 @default.
• W2489805306 cites W2005750374 @default.
• W2489805306 cites W2006816877 @default.
• W2489805306 cites W2007844697 @default.
• W2489805306 cites W2009576540 @default.
• W2489805306 cites W2010022403 @default.
• W2489805306 cites W2010049199 @default.
• W2489805306 cites W2010161321 @default.
• W2489805306 cites W2010255232 @default.
• W2489805306 cites W2011405307 @default.
• W2489805306 cites W2012223636 @default.
• W2489805306 cites W2013205740 @default.
• W2489805306 cites W2017218687 @default.
• W2489805306 cites W2019937806 @default.
• W2489805306 cites W2020301095 @default.
• W2489805306 cites W2020438000 @default.
• W2489805306 cites W2020977773 @default.
• W2489805306 cites W2021497478 @default.
• W2489805306 cites W2021798161 @default.
• W2489805306 cites W2023789925 @default.
• W2489805306 cites W2024131694 @default.
• W2489805306 cites W2029722028 @default.
• W2489805306 cites W2030205108 @default.
• W2489805306 cites W2031028006 @default.
• W2489805306 cites W2032580087 @default.
• W2489805306 cites W2033107200 @default.
• W2489805306 cites W2037512713 @default.
• W2489805306 cites W2037653294 @default.
• W2489805306 cites W2038260399 @default.

• next