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• W2489829906 startingPage "581" @default.
• W2489829906 abstract "This chapter provides a brief description of the complex grape chemistry, i.e., the great variety of metabolites synthesized by the plant and stored in different berry tissues. Health-promoting effects of grapevine products strictly depend on the potpourri of the chemicals present in grape tissues, phenylpropanoids, isoprenoids, and alkaloids, thus supporting the assumption that no particular compound is by itself responsible for the health benefits widely attributed to these plant foods and beverages. In the last decades, a lot of studies focused mainly on polyphenols, considered as the archetypes of grapevine product bioactivities. Grape seed extract shows promising efficacy against two important processes involved in cancer progression, angiogenesis and metastasis, inhibited in prostate and breast carcinoma, respectively. Because of increased metabolic activity and oxygen consumption of rapidly proliferating cells, solid tumors are likely to maintain an intratumoral hypoxic environment, which, in turn, induces a set of hypoxia-responsive genes in order to allow tumor cell adaptation. The expression of these genes is regulated by the hypoxia inducible factor, a major regulator of cellular oxygen homeostasis. Apart from the beneficial effects exerted by polyphenols, other types of tumors can benefit from regular, moderate consumption of grape products. Carcinomas of the digestive tract are common and their risk increases with age. In gastric cancer cells, resveratrol was shown to inhibit cell proliferation and to induce apoptosis." @default.
• W2489829906 created "2016-08-23" @default.
• W2489829906 creator A5021595304 @default.
• W2489829906 creator A5085209673 @default.
• W2489829906 date "2010-01-01" @default.
• W2489829906 modified "2023-10-03" @default.
• W2489829906 title "Bioactive Chemicals and Health Benefits of Grapevine Products" @default.
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