Matches in SemOpenAlex for { <https://semopenalex.org/work/W2489901630> ?p ?o ?g. }
- W2489901630 abstract "Abstract Anacetrapib is a potent and selective CETP inhibitor and is undergoing phase III clinical trials for the treatment of dyslipidemia. A simple and sensitive high‐performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS) method for the quantification of anacetrapib in rat plasma was developed and validated using an easily purchasable compound, chlorpropamide, as an internal standard (IS). A minimal volume of rat plasma sample (20 μL) was prepared by a single‐step deproteinization procedure with 80 μL of acetonitrile. Chromatographic separation was performed using Kinetex C 18 column with a gradient mobile phase consisting of water and acetonitrile containing 0.1% formic acid at a flow rate of 0.3 mL/min. Mass spectrometric detection was performed using selected reaction monitoring modes at the mass/charge transitions m/z 638 → 283 for anacetrapib and m/z 277 → 175 for IS. The assay was validated to demonstrate the selectivity, linearity, precision, accuracy, recovery, matrix effect and stability. The lower limit of quantification was 5 ng/mL. This LC‐MS/MS assay was successfully applied in the rat plasma protein binding and pharmacokinetic studies of anacetrapib. The fraction of unbound anacetrapib was determined to be low (ranging from 5.66 to 12.3%), and the absolute oral bioavailability of anacetrapib was 32.7%." @default.
- W2489901630 created "2016-08-23" @default.
- W2489901630 creator A5002912539 @default.
- W2489901630 creator A5019897388 @default.
- W2489901630 creator A5041445762 @default.
- W2489901630 creator A5048339883 @default.
- W2489901630 creator A5049751156 @default.
- W2489901630 creator A5058817322 @default.
- W2489901630 creator A5061294405 @default.
- W2489901630 creator A5065126365 @default.
- W2489901630 creator A5068288714 @default.
- W2489901630 creator A5078895940 @default.
- W2489901630 creator A5086925583 @default.
- W2489901630 creator A5088806568 @default.
- W2489901630 date "2016-08-08" @default.
- W2489901630 modified "2023-10-16" @default.
- W2489901630 title "Assessment of pharmacokinetics, bioavailability and protein binding of anacetrapib in rats by a simple high-performance liquid chromatography-tandem mass spectrometry method" @default.
- W2489901630 cites W1140732306 @default.
- W2489901630 cites W1491964893 @default.
- W2489901630 cites W1938187017 @default.
- W2489901630 cites W1978430613 @default.
- W2489901630 cites W1978716975 @default.
- W2489901630 cites W1983315526 @default.
- W2489901630 cites W2002741001 @default.
- W2489901630 cites W2005332332 @default.
- W2489901630 cites W2034473936 @default.
- W2489901630 cites W2046630860 @default.
- W2489901630 cites W2049789253 @default.
- W2489901630 cites W2061250936 @default.
- W2489901630 cites W2091367263 @default.
- W2489901630 cites W2091883594 @default.
- W2489901630 cites W2108297214 @default.
- W2489901630 cites W2129941946 @default.
- W2489901630 cites W2142003978 @default.
- W2489901630 cites W2166606079 @default.
- W2489901630 doi "https://doi.org/10.1002/bmc.3791" @default.
- W2489901630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27432781" @default.
- W2489901630 hasPublicationYear "2016" @default.
- W2489901630 type Work @default.
- W2489901630 sameAs 2489901630 @default.
- W2489901630 citedByCount "5" @default.
- W2489901630 countsByYear W24899016302017 @default.
- W2489901630 countsByYear W24899016302018 @default.
- W2489901630 countsByYear W24899016302019 @default.
- W2489901630 crossrefType "journal-article" @default.
- W2489901630 hasAuthorship W2489901630A5002912539 @default.
- W2489901630 hasAuthorship W2489901630A5019897388 @default.
- W2489901630 hasAuthorship W2489901630A5041445762 @default.
- W2489901630 hasAuthorship W2489901630A5048339883 @default.
- W2489901630 hasAuthorship W2489901630A5049751156 @default.
- W2489901630 hasAuthorship W2489901630A5058817322 @default.
- W2489901630 hasAuthorship W2489901630A5061294405 @default.
- W2489901630 hasAuthorship W2489901630A5065126365 @default.
- W2489901630 hasAuthorship W2489901630A5068288714 @default.
- W2489901630 hasAuthorship W2489901630A5078895940 @default.
- W2489901630 hasAuthorship W2489901630A5086925583 @default.
- W2489901630 hasAuthorship W2489901630A5088806568 @default.
- W2489901630 hasConcept C112705442 @default.
- W2489901630 hasConcept C119128265 @default.
- W2489901630 hasConcept C162356407 @default.
- W2489901630 hasConcept C179998833 @default.
- W2489901630 hasConcept C181389837 @default.
- W2489901630 hasConcept C185592680 @default.
- W2489901630 hasConcept C2777379063 @default.
- W2489901630 hasConcept C31827203 @default.
- W2489901630 hasConcept C43617362 @default.
- W2489901630 hasConcept C64489805 @default.
- W2489901630 hasConcept C71043704 @default.
- W2489901630 hasConcept C71924100 @default.
- W2489901630 hasConcept C98274493 @default.
- W2489901630 hasConceptScore W2489901630C112705442 @default.
- W2489901630 hasConceptScore W2489901630C119128265 @default.
- W2489901630 hasConceptScore W2489901630C162356407 @default.
- W2489901630 hasConceptScore W2489901630C179998833 @default.
- W2489901630 hasConceptScore W2489901630C181389837 @default.
- W2489901630 hasConceptScore W2489901630C185592680 @default.
- W2489901630 hasConceptScore W2489901630C2777379063 @default.
- W2489901630 hasConceptScore W2489901630C31827203 @default.
- W2489901630 hasConceptScore W2489901630C43617362 @default.
- W2489901630 hasConceptScore W2489901630C64489805 @default.
- W2489901630 hasConceptScore W2489901630C71043704 @default.
- W2489901630 hasConceptScore W2489901630C71924100 @default.
- W2489901630 hasConceptScore W2489901630C98274493 @default.
- W2489901630 hasIssue "2" @default.
- W2489901630 hasLocation W24899016301 @default.
- W2489901630 hasLocation W24899016302 @default.
- W2489901630 hasOpenAccess W2489901630 @default.
- W2489901630 hasPrimaryLocation W24899016301 @default.
- W2489901630 hasRelatedWork W1968381290 @default.
- W2489901630 hasRelatedWork W1968441093 @default.
- W2489901630 hasRelatedWork W1985701257 @default.
- W2489901630 hasRelatedWork W2018493658 @default.
- W2489901630 hasRelatedWork W2093402573 @default.
- W2489901630 hasRelatedWork W2120155947 @default.
- W2489901630 hasRelatedWork W2151017812 @default.
- W2489901630 hasRelatedWork W2167863534 @default.
- W2489901630 hasRelatedWork W4251012885 @default.
- W2489901630 hasRelatedWork W4323347615 @default.
- W2489901630 hasVolume "31" @default.
- W2489901630 isParatext "false" @default.