FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2490073190> ?p ?o ?g. }

• W2490073190 abstract "Abstract NLRP3 and ASC are able to form a large multimeric complex called inflammasome in response to a number danger signals. The NLRP3 inflammasome is required for the activation of caspase-1 and subsequent maturation of pro-IL-1β into active IL-1β. Although the mechanisms regulating the formation and activity of NLRP3 inflammasome are yet not fully elucidated, data suggest that the assembly of NLRP3 inflammasome requires microtubules to induce the proximity of ASC and NLRP3. In this study we show that microfilaments (F-actin) inhibit NLRP3 inflammasome activity and interact with NLRP3 and ASC. We demonstrate that the inhibition depends on the actin polymerization state but not on the active polymerization process. In ATP- or nigericin-activated macrophages, our data further indicate that Flightless-I (FliI) and leucine-rich repeat FliI-interaction protein 2 (LRRFIP2) are required for the co-localization of NLRP3, ASC and F-actin. We also established that the ability of Ca 2+ to accentuate the activity of NLRP3 inflammasome is abrogated in FliI- and LRRFIP2-knockdown macrophages, suggesting that Ca 2+ signaling requires the presence of FliI and LRRFIP2. Accordingly, we observed that Ca 2+ /FliI-dependent severing of F-actin suppresses F-actin/FliI/LRRFIP2-dependent NLRP3 inflammasome inhibition leading to increase IL-1β production. Altogether, our results unveil a new function of F-actin in the regulation of NLRP3 inflammasome activity strengthening the importance of cytoskeleton in the regulation of inflammation." @default.
• W2490073190 created "2016-08-23" @default.
• W2490073190 creator A5035122264 @default.
• W2490073190 creator A5044847332 @default.
• W2490073190 creator A5078135153 @default.
• W2490073190 creator A5084750013 @default.
• W2490073190 date "2016-07-19" @default.
• W2490073190 modified "2023-10-16" @default.
• W2490073190 title "F-actin dampens NLRP3 inflammasome activity via Flightless-I and LRRFIP2" @default.
• W2490073190 cites W1529674879 @default.
• W2490073190 cites W1859128422 @default.
• W2490073190 cites W1876413960 @default.
• W2490073190 cites W1925705209 @default.
• W2490073190 cites W1964159573 @default.
• W2490073190 cites W1969173609 @default.
• W2490073190 cites W1971915082 @default.
• W2490073190 cites W1975012711 @default.
• W2490073190 cites W1989168851 @default.
• W2490073190 cites W1990995529 @default.
• W2490073190 cites W1991494909 @default.
• W2490073190 cites W1999480476 @default.
• W2490073190 cites W2000117406 @default.
• W2490073190 cites W2001946532 @default.
• W2490073190 cites W2005846870 @default.
• W2490073190 cites W2009523990 @default.
• W2490073190 cites W2009800174 @default.
• W2490073190 cites W2014627448 @default.
• W2490073190 cites W2025695281 @default.
• W2490073190 cites W2026950841 @default.
• W2490073190 cites W2027027424 @default.
• W2490073190 cites W2033991414 @default.
• W2490073190 cites W2037600884 @default.
• W2490073190 cites W2043661964 @default.
• W2490073190 cites W2050449334 @default.
• W2490073190 cites W2076484864 @default.
• W2490073190 cites W2102769375 @default.
• W2490073190 cites W2108373994 @default.
• W2490073190 cites W2120118104 @default.
• W2490073190 cites W2126384811 @default.
• W2490073190 cites W2128190429 @default.
• W2490073190 cites W2135562187 @default.
• W2490073190 cites W2137334382 @default.
• W2490073190 cites W2145367033 @default.
• W2490073190 cites W2159587574 @default.
• W2490073190 cites W2162847025 @default.
• W2490073190 cites W2163802608 @default.
• W2490073190 cites W2170691646 @default.
• W2490073190 cites W2327553121 @default.
• W2490073190 cites W4211217520 @default.
• W2490073190 doi "https://doi.org/10.1038/srep29834" @default.
• W2490073190 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4949445" @default.
• W2490073190 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27431477" @default.
• W2490073190 hasPublicationYear "2016" @default.
• W2490073190 type Work @default.
• W2490073190 sameAs 2490073190 @default.
• W2490073190 citedByCount "34" @default.
• W2490073190 countsByYear W24900731902017 @default.
• W2490073190 countsByYear W24900731902018 @default.
• W2490073190 countsByYear W24900731902019 @default.
• W2490073190 countsByYear W24900731902020 @default.
• W2490073190 countsByYear W24900731902021 @default.
• W2490073190 countsByYear W24900731902022 @default.
• W2490073190 countsByYear W24900731902023 @default.
• W2490073190 crossrefType "journal-article" @default.
• W2490073190 hasAuthorship W2490073190A5035122264 @default.
• W2490073190 hasAuthorship W2490073190A5044847332 @default.
• W2490073190 hasAuthorship W2490073190A5078135153 @default.
• W2490073190 hasAuthorship W2490073190A5084750013 @default.
• W2490073190 hasBestOaLocation W24900731901 @default.
• W2490073190 hasConcept C125705527 @default.
• W2490073190 hasConcept C142669718 @default.
• W2490073190 hasConcept C1491633281 @default.
• W2490073190 hasConcept C170493617 @default.
• W2490073190 hasConcept C185592680 @default.
• W2490073190 hasConcept C20418707 @default.
• W2490073190 hasConcept C2777209026 @default.
• W2490073190 hasConcept C2777330628 @default.
• W2490073190 hasConcept C2993400109 @default.
• W2490073190 hasConcept C41625074 @default.
• W2490073190 hasConcept C55493867 @default.
• W2490073190 hasConcept C86803240 @default.
• W2490073190 hasConcept C95444343 @default.
• W2490073190 hasConceptScore W2490073190C125705527 @default.
• W2490073190 hasConceptScore W2490073190C142669718 @default.
• W2490073190 hasConceptScore W2490073190C1491633281 @default.
• W2490073190 hasConceptScore W2490073190C170493617 @default.
• W2490073190 hasConceptScore W2490073190C185592680 @default.
• W2490073190 hasConceptScore W2490073190C20418707 @default.
• W2490073190 hasConceptScore W2490073190C2777209026 @default.
• W2490073190 hasConceptScore W2490073190C2777330628 @default.
• W2490073190 hasConceptScore W2490073190C2993400109 @default.
• W2490073190 hasConceptScore W2490073190C41625074 @default.
• W2490073190 hasConceptScore W2490073190C55493867 @default.
• W2490073190 hasConceptScore W2490073190C86803240 @default.
• W2490073190 hasConceptScore W2490073190C95444343 @default.
• W2490073190 hasIssue "1" @default.
• W2490073190 hasLocation W24900731901 @default.
• W2490073190 hasLocation W24900731902 @default.
• W2490073190 hasLocation W24900731903 @default.
• W2490073190 hasLocation W24900731904 @default.

• next