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• W2490103644 abstract "Background and PurposeImiquimod is an immunomodulator approved for the treatment of basal cell carcinoma, and has adverse side effects resulting from the treatments, including taste disturbances. Paracrine transmission, representing cell-cell communication within taste buds, has the potential to shape the final signal output that taste buds transmit to the brain. The underlying assumption has been that imiquimod exerts its effects on taste transmitter secretion in taste buds of mice.Experimental ApproachTo test this assumption, we investigated whether transmitter release in taste buds is affected by imiquimod. Using calcium imaging with cellular biosensors, we examined the net effect of imiquimod on taste-evoked ATP secretion from mouse taste buds.Key ResultsOur results indicated that up to 72% of Presynaptic (Type III) taste cells responded to 100 μM imiquimod with an increase in intracellular Ca2+ responses. We demonstrated that Ca2+ responses were inhibited by thapsigargin, a sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) inhibitor, and by U73122, a phospholipase C (PLC) inhibitor, suggesting that imiquimod-elicited Ca2+ mobilization was dependent on internal Ca2+ store release. Moreover, combined studies of Ca2+ imaging with cellular biosensors revealed the imiquimod-evoked secretion of serotonin (5-HT), which provides negative feedback onto Receptor (Type II) cells to reduce taste-evoked ATP secretion.Conclusion and ImplicationsOur results provide evidence that there is a subset of taste cells equipped with diverse intracellular mechanisms that respond to imiquimod. The findings are also consistent with a role of imiquimod as an immune response modifier, which shapes peripheral taste responses via the serotonergic signaling pathway." @default.
• W2490103644 created "2016-08-23" @default.
• W2490103644 creator A5027383373 @default.
• W2490103644 creator A5089380452 @default.
• W2490103644 date "2016-09-06" @default.
• W2490103644 modified "2023-09-27" @default.
• W2490103644 title "The effect of imiquimod on taste bud calcium transients and transmitter secretion" @default.
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• W2490103644 doi "https://doi.org/10.1111/bph.13567" @default.
• W2490103644 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5056224" @default.
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• W2490103644 hasPublicationYear "2016" @default.
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