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• W2490147999 endingPage "169" @default.
• W2490147999 startingPage "111" @default.
• W2490147999 abstract "The monoamine neurotransmitters norepinephrine (NE), dopamine (DA), and serotonin (5-HT), play important roles in mood, cognition, learning, motor activity, reward, sleep, appetite, and cardiovascular functions. The availability of extracellular NE, DA, and 5-HT is limited by presynaptically localized transporters—NET, DAT, and SERT, respectively. The MA transporters retrieve released neurotransmitter, thus limiting the spread and duration of synaptic excitability and allowing neurotransmitter to be repackaged into synaptic vesicles. NET and SERT are the targets for many antidepressants, such as the tricyclic agents and the selective serotonin reuptake inhibitors (SSRIs) and with DAT, are the targets for the psychostimulants amphetamine and cocaine (1). NET, DAT and SERT form a subfamily within a larger gene family of 12 transmembrane domain (TMD)-containing, Na+and Cl–-coupled cotransporters which includes gamma-aminobutyric acid (GABA), glycine, proline, and taurine transporters. Amino-acid identity across the gene family and within the MA transporter subgroup is highest in the TMDs and boundaries—particularly TMD 1 and 2 and 4 through 8—and lowest in the amino and carboxy terminal regions and extracellular loops (ELs) (2). The large second EL contains consensus sites for glycosylation, which have been shown to play a role in transporter trafficking and stability (3,4) (see also Chapter 10). There are also potential sites for serine and threonine and tyrosine kinase phosphorylation in the aminoand carboxy-termini and cytoplasmic loops. Recent studies suggest an important role for protein kinases and phosphatases in the acute modulation of transporter trafficking and activity (5–8) (see also Chapters 1 and 10). Regions of highest sequence" @default.
• W2490147999 created "2016-08-23" @default.
• W2490147999 creator A5022425643 @default.
• W2490147999 creator A5025174055 @default.
• W2490147999 date "2003-11-14" @default.
• W2490147999 modified "2023-10-04" @default.
• W2490147999 title "Gene Organization and Polymorphisms of Monoamine Transporters: Relationship to Psychiatric and Other Complex Diseases" @default.
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