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- W2490216639 endingPage "1211" @default.
- W2490216639 startingPage "1189" @default.
- W2490216639 abstract "The identification and cloning of numerous cytokines over the last 20 years have provided new challenges for the scientist of today on how to translate this large amount of knowledge into therapeutic benefit. Cytokines plays a major role in a number of physiological and pathological processes including immunity, inflammation, repair, fibrosis, and cancer. Cytokines may be key or rate-limiting to the pathogenesis of rheumatoid arthritis, which lead to the definition of TNFα as a major therapeutic target. The success of anti-TNFα therapy in rheumatoid arthritis prompted anti-TNFα clinical trials in a number of related diseases, including Crohn's disease, psoriatic arthritis and ankylosing spondylitis, which also proved to be highly beneficial. This seems to be the beginning of a new wave of target therapies for a number of related inflammatory diseases that is going to be based on the increased understanding of disease pathogenesis, and the role cytokines play in that. Initially, this may take the form of anti-cytokine blocking agents, such as neutralizing antibodies and soluble receptors, but subsequently more specific therapeutic agents targeting the intracellular mechanisms involved in cytokine gene expression may predominate. Durability of the benefit, safety and pharmacoeconomic issues will determine whether this early promise will materialize and whether it will prove to be a major breakthrough for the treatment of incurable and painful diseases." @default.
- W2490216639 created "2016-08-23" @default.
- W2490216639 creator A5057580992 @default.
- W2490216639 creator A5066206791 @default.
- W2490216639 date "2003-01-01" @default.
- W2490216639 modified "2023-09-26" @default.
- W2490216639 title "Autoimmunity and cytokinesPathogenesis and therapy" @default.
- W2490216639 cites W132781887 @default.
- W2490216639 cites W1487018400 @default.
- W2490216639 cites W1490165777 @default.
- W2490216639 cites W1516892952 @default.
- W2490216639 cites W1528765374 @default.
- W2490216639 cites W1532072084 @default.
- W2490216639 cites W1537651169 @default.
- W2490216639 cites W1546831560 @default.
- W2490216639 cites W1558053349 @default.
- W2490216639 cites W1584114579 @default.
- W2490216639 cites W1597952938 @default.
- W2490216639 cites W1603555904 @default.
- W2490216639 cites W1606902694 @default.
- W2490216639 cites W1670891845 @default.
- W2490216639 cites W175055053 @default.
- W2490216639 cites W1783695128 @default.
- W2490216639 cites W1814428891 @default.
- W2490216639 cites W1870486979 @default.
- W2490216639 cites W1870510950 @default.
- W2490216639 cites W1892298186 @default.
- W2490216639 cites W1966103571 @default.
- W2490216639 cites W1967004332 @default.
- W2490216639 cites W1970287941 @default.
- W2490216639 cites W1970392021 @default.
- W2490216639 cites W1971685694 @default.
- W2490216639 cites W1973123086 @default.
- W2490216639 cites W1973652618 @default.
- W2490216639 cites W1973967947 @default.
- W2490216639 cites W1974066524 @default.
- W2490216639 cites W1974855426 @default.
- W2490216639 cites W1974903457 @default.
- W2490216639 cites W1975534320 @default.
- W2490216639 cites W1976262436 @default.
- W2490216639 cites W1976833987 @default.
- W2490216639 cites W1977773205 @default.
- W2490216639 cites W1978103379 @default.
- W2490216639 cites W1980480613 @default.
- W2490216639 cites W1980486933 @default.
- W2490216639 cites W1983541797 @default.
- W2490216639 cites W1983552305 @default.
- W2490216639 cites W1984648195 @default.
- W2490216639 cites W1985446981 @default.
- W2490216639 cites W1985643183 @default.
- W2490216639 cites W1985763670 @default.
- W2490216639 cites W1988280501 @default.
- W2490216639 cites W1988305410 @default.
- W2490216639 cites W1990226212 @default.
- W2490216639 cites W1990247622 @default.
- W2490216639 cites W1990436607 @default.
- W2490216639 cites W1991957995 @default.
- W2490216639 cites W1992512865 @default.
- W2490216639 cites W1995344305 @default.
- W2490216639 cites W1995557967 @default.
- W2490216639 cites W1995728045 @default.
- W2490216639 cites W1996472975 @default.
- W2490216639 cites W1996794055 @default.
- W2490216639 cites W1996899099 @default.
- W2490216639 cites W1997464096 @default.
- W2490216639 cites W1997638368 @default.
- W2490216639 cites W1999202157 @default.
- W2490216639 cites W2001354881 @default.
- W2490216639 cites W2002883352 @default.
- W2490216639 cites W2003652884 @default.
- W2490216639 cites W2004751481 @default.
- W2490216639 cites W2004966953 @default.
- W2490216639 cites W2005413201 @default.
- W2490216639 cites W2006439977 @default.
- W2490216639 cites W2006831045 @default.
- W2490216639 cites W2007606955 @default.
- W2490216639 cites W2010453211 @default.
- W2490216639 cites W2011437322 @default.
- W2490216639 cites W2011548322 @default.
- W2490216639 cites W2012542956 @default.
- W2490216639 cites W2012827463 @default.
- W2490216639 cites W2019393537 @default.
- W2490216639 cites W2019819289 @default.
- W2490216639 cites W2020250668 @default.
- W2490216639 cites W2020271584 @default.
- W2490216639 cites W2021781384 @default.
- W2490216639 cites W2022253360 @default.
- W2490216639 cites W2024162533 @default.
- W2490216639 cites W2025853481 @default.
- W2490216639 cites W2026256868 @default.
- W2490216639 cites W2026317814 @default.
- W2490216639 cites W2026342001 @default.
- W2490216639 cites W2026370029 @default.
- W2490216639 cites W2026507759 @default.
- W2490216639 cites W2031586032 @default.
- W2490216639 cites W2032666422 @default.
- W2490216639 cites W2032731042 @default.
- W2490216639 cites W2034306860 @default.