FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2490229396> ?p ?o ?g. }

• W2490229396 endingPage "65" @default.
• W2490229396 startingPage "65" @default.
• W2490229396 abstract "The procedures used to model a protein structure are well established when the novel protein has high sequence similarity to a protein of known structure. Many proteins of interest have low (i.e. <50%) sequence similarity to any known structure. In these cases new approaches to prediction of structure are required. The use of sequence profiles which relate sequence to known structure has been proposed as one method to assign local regions of structure. As a first stage, templates or icons of the many relevant substructural motifs found in proteins must be defined. The sequences which gave rise to these structures are then aligned and a weighted profile obtained. Average structures of the 8 and 12 residue helix-turn and turn-helix motifs have been prepared. These coordinate templates were then used to scan through the Brookhaven protein structural database for similar, superimposable fragments. A composite template of 100 similar fragments for each element was found to be internally consistent to a rmsd=0.92 Å for HT8, 1.54 Å for HT12, 0.41 Å for TH8 and 1.40 Å for TH12. All of the sequences, from these structures, were then used to create an overall sequence profile. The four sequence profiles were scanned against the amino acid sequences of the proteins in the Brookhaven database: tertiary structure was correctly identified only about 10% of the time. This value is too low for predictive purposes. However, it could be increased by checking for multiple occurrences of the template in one protein." @default.
• W2490229396 created "2016-08-23" @default.
• W2490229396 creator A5003833422 @default.
• W2490229396 date "1989-01-01" @default.
• W2490229396 modified "2023-09-23" @default.
• W2490229396 title "The use of structural templates in protein backbone modeling" @default.
• W2490229396 cites W1508885706 @default.
• W2490229396 cites W1527979595 @default.
• W2490229396 cites W1565582771 @default.
• W2490229396 cites W1574312817 @default.
• W2490229396 cites W1606011614 @default.
• W2490229396 cites W1965103520 @default.
• W2490229396 cites W1966041739 @default.
• W2490229396 cites W1971251199 @default.
• W2490229396 cites W1971853518 @default.
• W2490229396 cites W1975736414 @default.
• W2490229396 cites W1980680467 @default.
• W2490229396 cites W1991206565 @default.
• W2490229396 cites W1996924859 @default.
• W2490229396 cites W1998616079 @default.
• W2490229396 cites W1999473806 @default.
• W2490229396 cites W2000204882 @default.
• W2490229396 cites W2001365663 @default.
• W2490229396 cites W2007415752 @default.
• W2490229396 cites W2009310436 @default.
• W2490229396 cites W2010919933 @default.
• W2490229396 cites W2012334384 @default.
• W2490229396 cites W2019651515 @default.
• W2490229396 cites W2021331983 @default.
• W2490229396 cites W2024552188 @default.
• W2490229396 cites W2025408524 @default.
• W2490229396 cites W2026185422 @default.
• W2490229396 cites W2030135244 @default.
• W2490229396 cites W2036324972 @default.
• W2490229396 cites W2044042024 @default.
• W2490229396 cites W2056393938 @default.
• W2490229396 cites W2070383082 @default.
• W2490229396 cites W2078051636 @default.
• W2490229396 cites W2081359387 @default.
• W2490229396 cites W2090338919 @default.
• W2490229396 cites W2091378967 @default.
• W2490229396 cites W2115042613 @default.
• W2490229396 cites W2123333780 @default.
• W2490229396 cites W2125793518 @default.
• W2490229396 cites W2129999032 @default.
• W2490229396 cites W2140998261 @default.
• W2490229396 cites W2165812178 @default.
• W2490229396 cites W2177861138 @default.
• W2490229396 cites W2342729031 @default.
• W2490229396 cites W4243946486 @default.
• W2490229396 cites W2047441128 @default.
• W2490229396 doi "https://doi.org/10.6028/jres.094.009" @default.
• W2490229396 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4954596" @default.
• W2490229396 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28053400" @default.
• W2490229396 hasPublicationYear "1989" @default.
• W2490229396 type Work @default.
• W2490229396 sameAs 2490229396 @default.
• W2490229396 citedByCount "0" @default.
• W2490229396 crossrefType "journal-article" @default.
• W2490229396 hasAuthorship W2490229396A5003833422 @default.
• W2490229396 hasBestOaLocation W24902293961 @default.
• W2490229396 hasConcept C10010492 @default.
• W2490229396 hasConcept C103278499 @default.
• W2490229396 hasConcept C104317684 @default.
• W2490229396 hasConcept C115961682 @default.
• W2490229396 hasConcept C132677234 @default.
• W2490229396 hasConcept C136475424 @default.
• W2490229396 hasConcept C139489369 @default.
• W2490229396 hasConcept C154945302 @default.
• W2490229396 hasConcept C167625842 @default.
• W2490229396 hasConcept C18051474 @default.
• W2490229396 hasConcept C199360897 @default.
• W2490229396 hasConcept C2778112365 @default.
• W2490229396 hasConcept C41008148 @default.
• W2490229396 hasConcept C41584329 @default.
• W2490229396 hasConcept C45475804 @default.
• W2490229396 hasConcept C45484198 @default.
• W2490229396 hasConcept C47701112 @default.
• W2490229396 hasConcept C54355233 @default.
• W2490229396 hasConcept C55493867 @default.
• W2490229396 hasConcept C62614982 @default.
• W2490229396 hasConcept C70721500 @default.
• W2490229396 hasConcept C75599170 @default.
• W2490229396 hasConcept C82714645 @default.
• W2490229396 hasConcept C86803240 @default.
• W2490229396 hasConceptScore W2490229396C10010492 @default.
• W2490229396 hasConceptScore W2490229396C103278499 @default.
• W2490229396 hasConceptScore W2490229396C104317684 @default.
• W2490229396 hasConceptScore W2490229396C115961682 @default.
• W2490229396 hasConceptScore W2490229396C132677234 @default.
• W2490229396 hasConceptScore W2490229396C136475424 @default.
• W2490229396 hasConceptScore W2490229396C139489369 @default.
• W2490229396 hasConceptScore W2490229396C154945302 @default.
• W2490229396 hasConceptScore W2490229396C167625842 @default.
• W2490229396 hasConceptScore W2490229396C18051474 @default.
• W2490229396 hasConceptScore W2490229396C199360897 @default.
• W2490229396 hasConceptScore W2490229396C2778112365 @default.
• W2490229396 hasConceptScore W2490229396C41008148 @default.

• next