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- W2490363436 abstract "Most of the animal models discussed in this chapter have predictive validity for certain components of the addiction cycle and generate reliable effects in animals. Achieving predictive validity is more problematic for constructs such as craving because of the nebulous conceptualizations and various definitions of craving in humans. Virtually all of the measures described here for animal models of addiction have demonstrated reliability, consistency, stability of the measures, small within-subject and between-subject variability, and reproducibility of the phenomena. Much remains to be explored about the face validity and predictive validity of unconditioned positive and negative motivational states, particularly the conditioned positive and negative motivational states associated with drug use and withdrawal. Determining the specific changes in the central nervous system associated with these models will provide further insights into both drug dependence and psychopathologies associated with anxiety and affective disorders. Animal models of addiction provide the foundation to begin such studies." @default.
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- W2490363436 date "2014-01-01" @default.
- W2490363436 modified "2023-10-14" @default.
- W2490363436 title "Animal Models of Addiction" @default.
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- W2490363436 doi "https://doi.org/10.1016/b978-0-12-386937-1.00003-9" @default.
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