Matches in SemOpenAlex for { <https://semopenalex.org/work/W2490366953> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2490366953 abstract "Background: Chronic hepatitis B virus (HBV) infection early in the life confers a high risk of chronicity, particularly in children born to highly viremic mothers, due to “viral vaccine breakthrough” phenomenon that could be treated by antivirals such as lamivudine and recently tenofovir.Objective: We evaluated efficacy and safety of lamivudine and tenofovir in late pregnancy in preventing perinatal transmission of hepatitis B virus (HBV) to infants born to highly viremic mothers.Materials and Methods: A total of 82 pregnant chronic HBsAg+ women with high viremia (>107 copies/mL) at 32 weeks of gestation were randomly assigned to 2 groups (lamivudine 100 mg or tenofovir 300 mg daily from 8 weeks of prepartum to week 4 postpartum). Infants received recombinant HBV vaccine without HBIg and were followed until week 52.Results: HBV perinatal trasmission rate, defined by HBsAg presence in children’s blood at week 52, was only 1.2% (1/82). The mean maternal viral load sharply decreased from 5.09 x 108 ± 3.19 x 108 copies/mL at week 32 of gestation to 1.13 x 106 ± 3.91 x 106 at labor (p<0.001). The viral load reduction was stronger in tenofovir-treated mothers than in lamivudine-treated ones (p<0.028), particularly in 4 log10 reduction (p<0.001). No viral resistance to the drugs was noted. Drug adverse events were rare and transient, allowing complete full course in all cases, and flare was seen in no case.Conclusion: Both lamivudine and tenofovir exhibited a high efficacy in preventing mother-to-child perinatal transmission of HBV and a good safety without viral resistance." @default.
- W2490366953 created "2016-08-23" @default.
- W2490366953 creator A5011548097 @default.
- W2490366953 creator A5042010410 @default.
- W2490366953 date "2015-01-01" @default.
- W2490366953 modified "2023-10-17" @default.
- W2490366953 title "Efficacy and Safety of Tenofovir and Lamivudine in Late Pregnancy for Preventing Perinatal Transmission of Hepatitis B Virus in Highly Viremic Mothers" @default.
- W2490366953 doi "https://doi.org/10.21767/2386-5180.10009" @default.
- W2490366953 hasPublicationYear "2015" @default.
- W2490366953 type Work @default.
- W2490366953 sameAs 2490366953 @default.
- W2490366953 citedByCount "0" @default.
- W2490366953 crossrefType "journal-article" @default.
- W2490366953 hasAuthorship W2490366953A5011548097 @default.
- W2490366953 hasAuthorship W2490366953A5042010410 @default.
- W2490366953 hasBestOaLocation W24903669531 @default.
- W2490366953 hasConcept C119599485 @default.
- W2490366953 hasConcept C126322002 @default.
- W2490366953 hasConcept C127413603 @default.
- W2490366953 hasConcept C131872663 @default.
- W2490366953 hasConcept C142462285 @default.
- W2490366953 hasConcept C159047783 @default.
- W2490366953 hasConcept C2522874641 @default.
- W2490366953 hasConcept C2776185481 @default.
- W2490366953 hasConcept C2777382497 @default.
- W2490366953 hasConcept C2777410769 @default.
- W2490366953 hasConcept C2777869810 @default.
- W2490366953 hasConcept C2779234561 @default.
- W2490366953 hasConcept C2779344132 @default.
- W2490366953 hasConcept C2780593183 @default.
- W2490366953 hasConcept C3013748606 @default.
- W2490366953 hasConcept C54355233 @default.
- W2490366953 hasConcept C71924100 @default.
- W2490366953 hasConcept C761482 @default.
- W2490366953 hasConcept C86803240 @default.
- W2490366953 hasConceptScore W2490366953C119599485 @default.
- W2490366953 hasConceptScore W2490366953C126322002 @default.
- W2490366953 hasConceptScore W2490366953C127413603 @default.
- W2490366953 hasConceptScore W2490366953C131872663 @default.
- W2490366953 hasConceptScore W2490366953C142462285 @default.
- W2490366953 hasConceptScore W2490366953C159047783 @default.
- W2490366953 hasConceptScore W2490366953C2522874641 @default.
- W2490366953 hasConceptScore W2490366953C2776185481 @default.
- W2490366953 hasConceptScore W2490366953C2777382497 @default.
- W2490366953 hasConceptScore W2490366953C2777410769 @default.
- W2490366953 hasConceptScore W2490366953C2777869810 @default.
- W2490366953 hasConceptScore W2490366953C2779234561 @default.
- W2490366953 hasConceptScore W2490366953C2779344132 @default.
- W2490366953 hasConceptScore W2490366953C2780593183 @default.
- W2490366953 hasConceptScore W2490366953C3013748606 @default.
- W2490366953 hasConceptScore W2490366953C54355233 @default.
- W2490366953 hasConceptScore W2490366953C71924100 @default.
- W2490366953 hasConceptScore W2490366953C761482 @default.
- W2490366953 hasConceptScore W2490366953C86803240 @default.
- W2490366953 hasLocation W24903669531 @default.
- W2490366953 hasOpenAccess W2490366953 @default.
- W2490366953 hasPrimaryLocation W24903669531 @default.
- W2490366953 hasRelatedWork W1964395865 @default.
- W2490366953 hasRelatedWork W2011891697 @default.
- W2490366953 hasRelatedWork W2021109749 @default.
- W2490366953 hasRelatedWork W2025999911 @default.
- W2490366953 hasRelatedWork W2042084902 @default.
- W2490366953 hasRelatedWork W2053051468 @default.
- W2490366953 hasRelatedWork W2054446257 @default.
- W2490366953 hasRelatedWork W2055439618 @default.
- W2490366953 hasRelatedWork W2057914232 @default.
- W2490366953 hasRelatedWork W2067318056 @default.
- W2490366953 hasRelatedWork W2104102513 @default.
- W2490366953 hasRelatedWork W2142974747 @default.
- W2490366953 hasRelatedWork W2169574907 @default.
- W2490366953 hasRelatedWork W229178404 @default.
- W2490366953 hasRelatedWork W2393041576 @default.
- W2490366953 hasRelatedWork W2400933536 @default.
- W2490366953 hasRelatedWork W2974056678 @default.
- W2490366953 hasRelatedWork W3028861662 @default.
- W2490366953 hasRelatedWork W3152480135 @default.
- W2490366953 hasRelatedWork W2470757816 @default.
- W2490366953 isParatext "false" @default.
- W2490366953 isRetracted "false" @default.
- W2490366953 magId "2490366953" @default.
- W2490366953 workType "article" @default.