FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2490541557> ?p ?o ?g. }

• W2490541557 endingPage "398" @default.
• W2490541557 startingPage "371" @default.
• W2490541557 abstract "Carbon metabolism of Plasmodium has attracted renewed interest. Advanced reverse genetics and analytical technologies allowed dissecting intermediary carbon metabolism of malaria parasites and assessing and validating its suitability for drug discovery. It was corroborated that anaerobic glycolysis is the major energy-generating pathway during intraerythrocytic life of the parasites while sexual development appears to rely much more on mitochondrial activity. The roles of parasite-specific metabolic adaptations such as carbon dioxide fixation via phosphoenolpyruvate carboxylase will be discussed especially as this diversion from glycolysis is indispensable for the human malaria parasite Plasmodium falciparum at least in vitro. It is well established that maintaining the electrochemical gradient across the inner mitochondrial membrane is vital for parasite survival, and atovaquone in combination with proguanil is the antimalarial in clinical use that takes advantage of the essential function of the mitochondrial electron transport chain. Other essential pathways suitable for drug discovery linked to carbon metabolism are those found in the parasite's plastid-like organelle, the apicoplast. The most promising is the biosynthesis of isopentenyl-pyrophosphate, which has been identified as the raison d'être of the organelle. Other targets, which affect liver-stage development of the parasites when inhibited, are the type II fatty acid biosynthesis (FASII) and the pyruvate dehydrogenase complex (PDC) present in the organelle, and it has been suggested that sexual development in the mosquito is affected by the loss of FAS II and PDC in the human malaria species P. falciparum. An important aspect of drug discovery against human malaria that needs to be taken into account is that different Plasmodium species have distinct metabolic requirements, which depend on their host cell environment, and this may impact on the suitability of a potential drug target." @default.
• W2490541557 created "2016-08-23" @default.
• W2490541557 creator A5045813596 @default.
• W2490541557 creator A5087971903 @default.
• W2490541557 date "2016-07-25" @default.
• W2490541557 modified "2023-10-12" @default.
• W2490541557 title "Carbon Metabolism of <i>Plasmodium falciparum</i>" @default.
• W2490541557 cites W119894908 @default.
• W2490541557 cites W1486654105 @default.
• W2490541557 cites W1499640952 @default.
• W2490541557 cites W1512031035 @default.
• W2490541557 cites W1549421076 @default.
• W2490541557 cites W1551921975 @default.
• W2490541557 cites W1557292478 @default.
• W2490541557 cites W1605944146 @default.
• W2490541557 cites W1965201403 @default.
• W2490541557 cites W1966127418 @default.
• W2490541557 cites W1966864334 @default.
• W2490541557 cites W1967195892 @default.
• W2490541557 cites W1967940636 @default.
• W2490541557 cites W1968364488 @default.
• W2490541557 cites W1969503178 @default.
• W2490541557 cites W1974544457 @default.
• W2490541557 cites W1974548275 @default.
• W2490541557 cites W1976726864 @default.
• W2490541557 cites W1976977157 @default.
• W2490541557 cites W1977123265 @default.
• W2490541557 cites W1980580072 @default.
• W2490541557 cites W1980779058 @default.
• W2490541557 cites W1985943082 @default.
• W2490541557 cites W1987727817 @default.
• W2490541557 cites W1990741430 @default.
• W2490541557 cites W1991428528 @default.
• W2490541557 cites W1991958185 @default.
• W2490541557 cites W1992637245 @default.
• W2490541557 cites W1994184498 @default.
• W2490541557 cites W1994915198 @default.
• W2490541557 cites W1994981979 @default.
• W2490541557 cites W1996682530 @default.
• W2490541557 cites W1999332954 @default.
• W2490541557 cites W2000800638 @default.
• W2490541557 cites W2001017384 @default.
• W2490541557 cites W2002470519 @default.
• W2490541557 cites W2002701887 @default.
• W2490541557 cites W2004210756 @default.
• W2490541557 cites W2005044534 @default.
• W2490541557 cites W2007561244 @default.
• W2490541557 cites W2008294932 @default.
• W2490541557 cites W2008555758 @default.
• W2490541557 cites W2009530683 @default.
• W2490541557 cites W2013691710 @default.
• W2490541557 cites W2014233120 @default.
• W2490541557 cites W2014258732 @default.
• W2490541557 cites W2018182528 @default.
• W2490541557 cites W2018861292 @default.
• W2490541557 cites W2019851585 @default.
• W2490541557 cites W2020018712 @default.
• W2490541557 cites W2023224492 @default.
• W2490541557 cites W2024295937 @default.
• W2490541557 cites W2029367458 @default.
• W2490541557 cites W2030488581 @default.
• W2490541557 cites W2030706796 @default.
• W2490541557 cites W2031257231 @default.
• W2490541557 cites W2034572121 @default.
• W2490541557 cites W2035278404 @default.
• W2490541557 cites W2035816104 @default.
• W2490541557 cites W2036415784 @default.
• W2490541557 cites W2036974378 @default.
• W2490541557 cites W2037024376 @default.
• W2490541557 cites W2037147152 @default.
• W2490541557 cites W2040590007 @default.
• W2490541557 cites W2042144226 @default.
• W2490541557 cites W2049904278 @default.
• W2490541557 cites W2050329917 @default.
• W2490541557 cites W2058051761 @default.
• W2490541557 cites W2060407236 @default.
• W2490541557 cites W2061680825 @default.
• W2490541557 cites W2061822300 @default.
• W2490541557 cites W2064987052 @default.
• W2490541557 cites W2064997088 @default.
• W2490541557 cites W2067383132 @default.
• W2490541557 cites W2069827730 @default.
• W2490541557 cites W2071064508 @default.
• W2490541557 cites W2072480910 @default.
• W2490541557 cites W2072768427 @default.
• W2490541557 cites W2074431213 @default.
• W2490541557 cites W2075149831 @default.
• W2490541557 cites W2077159435 @default.
• W2490541557 cites W2079916438 @default.
• W2490541557 cites W2079968363 @default.
• W2490541557 cites W2080120147 @default.
• W2490541557 cites W2081347878 @default.
• W2490541557 cites W2085804469 @default.
• W2490541557 cites W2085835962 @default.
• W2490541557 cites W2088322165 @default.
• W2490541557 cites W2089337157 @default.
• W2490541557 cites W2091585581 @default.
• W2490541557 cites W2093285833 @default.

• next