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• W2490564440 startingPage "187" @default.
• W2490564440 abstract "Abstract Melatonin is an ubiquitous molecule with a variety of functions including potent antioxidative properties. Due to its lipophilic character, it easily crosses cellular and intracellular membranes and reaches all subcellular organelles. Because of its ability to scavenge free radicals, melatonin protects against oxidative stress, for example, induced by ultraviolet radiation ( UVR ). Here, we investigated, in a dose‐dependent (0, 10, 25, and 50 mJ/cm 2 ) and time‐dependent (0, 4, 24, 48 hr post‐ UVR ) manner, whether melatonin prevents the UVR ‐mediated alterations in ATP synthesis and the generation of reactive oxygen species ( ROS ) in normal human epidermal keratinocytes ( NHEK ). Additionally, we evaluated the molecular mechanism of action of melatonin with regard to activation of phase‐2 antioxidative enzymes via nuclear erythroid 2‐related factor (Nrf2). We found that (i) melatonin counteracted UVR ‐induced alterations in the ATP synthesis and reduced free radical formation; (ii) melatonin induced the translocation of Nrf2 transcription factor from the cytosol into the nucleus resulting in, (iii) melatonin enhanced gene expression of phase‐2 antioxidative enzymes including γ ‐glutamylcysteine synthetase ( γ ‐ GCS ), heme oxygenase‐1 ( HO ‐1), and NADPH : quinone dehydrogenase‐1 ( NQO 1) representing an elevated antioxidative response of keratinocytes. These results suggest that melatonin not only directly scavenges ROS , but also significantly induces the activation of phase‐2 antioxidative enzymes via the Nrf2 pathway uncovering a new action mechanism that supports the ability of keratinocytes to protect themselves from UVR ‐mediated oxidative stress." @default.
• W2490564440 created "2016-08-23" @default.
• W2490564440 creator A5002451886 @default.
• W2490564440 creator A5081581216 @default.
• W2490564440 creator A5090549024 @default.
• W2490564440 date "2016-05-21" @default.
• W2490564440 modified "2023-10-13" @default.
• W2490564440 title "Melatonin enhances mitochondrial ATP synthesis, reduces reactive oxygen species formation, and mediates translocation of the nuclear erythroid 2-related factor 2 resulting in activation of phase-2 antioxidant enzymes (γ-GCS, HO-1, NQO1) in ultraviolet rad" @default.
• W2490564440 cites W1589667911 @default.
• W2490564440 cites W1731932233 @default.
• W2490564440 cites W1754595315 @default.
• W2490564440 cites W181903513 @default.
• W2490564440 cites W1915186499 @default.
• W2490564440 cites W1928584086 @default.
• W2490564440 cites W1970075441 @default.
• W2490564440 cites W1970991763 @default.
• W2490564440 cites W1982413554 @default.
• W2490564440 cites W1983889779 @default.
• W2490564440 cites W1985925844 @default.
• W2490564440 cites W1987808660 @default.
• W2490564440 cites W1994979888 @default.
• W2490564440 cites W1996684193 @default.
• W2490564440 cites W2002927314 @default.
• W2490564440 cites W2007361012 @default.
• W2490564440 cites W2012045241 @default.
• W2490564440 cites W2018360450 @default.
• W2490564440 cites W2019399071 @default.
• W2490564440 cites W2020736043 @default.
• W2490564440 cites W2023092740 @default.
• W2490564440 cites W2031661979 @default.
• W2490564440 cites W2036555813 @default.
• W2490564440 cites W2040232546 @default.
• W2490564440 cites W2041379622 @default.
• W2490564440 cites W2042100067 @default.
• W2490564440 cites W2043640322 @default.
• W2490564440 cites W2043774516 @default.
• W2490564440 cites W2043934719 @default.
• W2490564440 cites W2045045758 @default.
• W2490564440 cites W2045283564 @default.
• W2490564440 cites W2049453065 @default.
• W2490564440 cites W2054744426 @default.
• W2490564440 cites W2061388332 @default.
• W2490564440 cites W2062196582 @default.
• W2490564440 cites W2065837351 @default.
• W2490564440 cites W2065928158 @default.
• W2490564440 cites W2066334693 @default.
• W2490564440 cites W2068661217 @default.
• W2490564440 cites W2071290346 @default.
• W2490564440 cites W2072210888 @default.
• W2490564440 cites W2072317074 @default.
• W2490564440 cites W2072622931 @default.
• W2490564440 cites W2087406053 @default.
• W2490564440 cites W2091365164 @default.
• W2490564440 cites W2100130506 @default.
• W2490564440 cites W2107668207 @default.
• W2490564440 cites W2108358101 @default.
• W2490564440 cites W2111501638 @default.
• W2490564440 cites W2114689416 @default.
• W2490564440 cites W2115531251 @default.
• W2490564440 cites W2125373960 @default.
• W2490564440 cites W2127384718 @default.
• W2490564440 cites W2130507182 @default.
• W2490564440 cites W2136350449 @default.
• W2490564440 cites W2146558971 @default.
• W2490564440 cites W2156108044 @default.
• W2490564440 cites W2158151332 @default.
• W2490564440 cites W2158680852 @default.
• W2490564440 cites W2159517627 @default.
• W2490564440 cites W2160247027 @default.
• W2490564440 cites W2166266598 @default.
• W2490564440 cites W2171135124 @default.
• W2490564440 cites W2225347805 @default.
• W2490564440 cites W2239083587 @default.
• W2490564440 cites W2257332259 @default.
• W2490564440 cites W2278293559 @default.
• W2490564440 cites W2293782839 @default.
• W2490564440 cites W254640820 @default.
• W2490564440 cites W59586672 @default.
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• W2490564440 doi "https://doi.org/10.1111/jpi.12338" @default.
• W2490564440 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27117941" @default.
• W2490564440 hasPublicationYear "2016" @default.
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