Matches in SemOpenAlex for { <https://semopenalex.org/work/W2490633688> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2490633688 abstract "Abstract Presenilin 1 (PS1) and PS2 are evolutionarily conserved transmembrane proteins of the aspartyl protease family. Initially, they were reported to be associated with the early onset of familial, early-onset Alzheimer’s disease. PS1 has been implicated in several crucial brain functions including developmental processes, synaptic plasticity, and processing of various molecules, while PS2 has been poorly studied and is considered to be a compensatory partner of PS1. Certain controversial reports have suggested that PS2 has a role in apoptosis, though the underlying mechanism is not clear. To ascertain the role of PS2 in apoptosis, mouse neuroblastoma cells (Neuro2a) were transfected with a cDNA construct encoding full length mouse PS2 and analyzed for viability, expression of PS1, PS2, Bax and p53, Bax protein, and status of chromatin condensation. Our results showed reduced viability, condensed chromatin and higher expression of Bax at mRNA and protein levels, but no change in the expression of p53 and PS1 in PS2-overexpressing Neuro2a cells. Thus, it is evident that PS2, independent of PS1, is associated with apoptosis via a Bax-mediated pathway. These findings might help in the understanding of the involvement of PS2 in apoptosis and its associated brain disorders." @default.
- W2490633688 created "2016-08-23" @default.
- W2490633688 creator A5031658991 @default.
- W2490633688 creator A5063303135 @default.
- W2490633688 creator A5065242465 @default.
- W2490633688 date "2016-01-01" @default.
- W2490633688 modified "2023-09-27" @default.
- W2490633688 title "Presenilin 2 overexpression is associated with apoptosis in Neuro2a cells" @default.
- W2490633688 cites W1501858762 @default.
- W2490633688 cites W1513242172 @default.
- W2490633688 cites W1539469412 @default.
- W2490633688 cites W1627837349 @default.
- W2490633688 cites W1964839543 @default.
- W2490633688 cites W1970596167 @default.
- W2490633688 cites W1972311745 @default.
- W2490633688 cites W1983022185 @default.
- W2490633688 cites W1985195144 @default.
- W2490633688 cites W2010550564 @default.
- W2490633688 cites W2023144237 @default.
- W2490633688 cites W2025242397 @default.
- W2490633688 cites W2027173093 @default.
- W2490633688 cites W2034796667 @default.
- W2490633688 cites W2035030715 @default.
- W2490633688 cites W2038634903 @default.
- W2490633688 cites W2040093488 @default.
- W2490633688 cites W2043668598 @default.
- W2490633688 cites W2045153164 @default.
- W2490633688 cites W2046209489 @default.
- W2490633688 cites W2047943184 @default.
- W2490633688 cites W2050538294 @default.
- W2490633688 cites W2058913808 @default.
- W2490633688 cites W2067521893 @default.
- W2490633688 cites W2072907887 @default.
- W2490633688 cites W2074329168 @default.
- W2490633688 cites W2078804787 @default.
- W2490633688 cites W2083421096 @default.
- W2490633688 cites W2089496934 @default.
- W2490633688 cites W2093664104 @default.
- W2490633688 cites W2108732960 @default.
- W2490633688 cites W2144558114 @default.
- W2490633688 doi "https://doi.org/10.1515/tnsci-2016-0011" @default.
- W2490633688 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5234515" @default.
- W2490633688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28123824" @default.
- W2490633688 hasPublicationYear "2016" @default.
- W2490633688 type Work @default.
- W2490633688 sameAs 2490633688 @default.
- W2490633688 citedByCount "4" @default.
- W2490633688 countsByYear W24906336882017 @default.
- W2490633688 countsByYear W24906336882022 @default.
- W2490633688 crossrefType "journal-article" @default.
- W2490633688 hasAuthorship W2490633688A5031658991 @default.
- W2490633688 hasAuthorship W2490633688A5063303135 @default.
- W2490633688 hasAuthorship W2490633688A5065242465 @default.
- W2490633688 hasBestOaLocation W24906336881 @default.
- W2490633688 hasConcept C104317684 @default.
- W2490633688 hasConcept C126322002 @default.
- W2490633688 hasConcept C175344181 @default.
- W2490633688 hasConcept C190283241 @default.
- W2490633688 hasConcept C2779134260 @default.
- W2490633688 hasConcept C502032728 @default.
- W2490633688 hasConcept C54009773 @default.
- W2490633688 hasConcept C54355233 @default.
- W2490633688 hasConcept C71924100 @default.
- W2490633688 hasConcept C83640560 @default.
- W2490633688 hasConcept C86803240 @default.
- W2490633688 hasConcept C95444343 @default.
- W2490633688 hasConceptScore W2490633688C104317684 @default.
- W2490633688 hasConceptScore W2490633688C126322002 @default.
- W2490633688 hasConceptScore W2490633688C175344181 @default.
- W2490633688 hasConceptScore W2490633688C190283241 @default.
- W2490633688 hasConceptScore W2490633688C2779134260 @default.
- W2490633688 hasConceptScore W2490633688C502032728 @default.
- W2490633688 hasConceptScore W2490633688C54009773 @default.
- W2490633688 hasConceptScore W2490633688C54355233 @default.
- W2490633688 hasConceptScore W2490633688C71924100 @default.
- W2490633688 hasConceptScore W2490633688C83640560 @default.
- W2490633688 hasConceptScore W2490633688C86803240 @default.
- W2490633688 hasConceptScore W2490633688C95444343 @default.
- W2490633688 hasLocation W24906336881 @default.
- W2490633688 hasLocation W24906336882 @default.
- W2490633688 hasLocation W24906336883 @default.
- W2490633688 hasLocation W24906336884 @default.
- W2490633688 hasLocation W24906336885 @default.
- W2490633688 hasOpenAccess W2490633688 @default.
- W2490633688 hasPrimaryLocation W24906336881 @default.
- W2490633688 hasRelatedWork W1158298170 @default.
- W2490633688 hasRelatedWork W123250343 @default.
- W2490633688 hasRelatedWork W1983507144 @default.
- W2490633688 hasRelatedWork W2013095276 @default.
- W2490633688 hasRelatedWork W2072607348 @default.
- W2490633688 hasRelatedWork W2171277769 @default.
- W2490633688 hasRelatedWork W2347572046 @default.
- W2490633688 hasRelatedWork W2380732903 @default.
- W2490633688 hasRelatedWork W3004515236 @default.
- W2490633688 hasRelatedWork W4255802083 @default.
- W2490633688 isParatext "false" @default.
- W2490633688 isRetracted "false" @default.
- W2490633688 magId "2490633688" @default.
- W2490633688 workType "article" @default.