FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2490734223> ?p ?o ?g. }

• W2490734223 endingPage "2859" @default.
• W2490734223 startingPage "2853" @default.
• W2490734223 abstract "Nitidine chloride (NC) exhibits anti-tumor properties in various types of tumor. However, to the best of our knowledge there is no previous evidence of NC involvement in the apoptosis or proliferation of ovarian cancer cells and the underlying molecular mechanisms. The present study aimed to investigate the influence of NC on the viability and apoptosis of ovarian cancer cells and the synergistic effect NC and doxorubicin (DOX) may have on ovarian cancer cells. The viability and proliferation of ovarian cancer cells were examined using a methyl thiazolyl tetrazolium assay and 3H-thymidine incorporation assay. The apoptotic rate of ovarian cancer cells was detected by flow cytometry. The expression of apoptosis‑associated proteins and Akt serine/threonine kinase 1 (Akt) were determined by western blot analysis following NC treatment. The inhibitory effect of NC on the proliferation of ovarian cancer cells was demonstrated in a time and dose‑dependent manner. The pro-apoptotic effect of NC on ovarian cancer cells was also observed. It was determined that NC significantly downregulated the protein expression levels of B‑cell CLL/lymphoma 2 (Bcl-2) and upregulated the expression of Bcl‑2‑associated X protein, p53, caspase‑3 and ‑9. NC suppressed Akt phosphorylation. Additionally, the present study demonstrated that the effect of NC on the proliferation and apoptosis of ovarian cancer cells was Akt‑dependent by using the phosphatidylinositol-4,5-bisphosphate 3-kinase/Akt signaling pathway inhibitor, LY294002. NC exhibited a synergistic inhibitory effect on the viability of ovarian cancer cells when combined with DOX. The current study demonstrated that NC inhibited the proliferation and induced the apoptosis of ovarian cancer cells via the Akt signaling pathway and highlighted its potential clinical application for the treatment of ovarian cancer." @default.
• W2490734223 created "2016-08-23" @default.
• W2490734223 creator A5003738753 @default.
• W2490734223 creator A5006159092 @default.
• W2490734223 creator A5007433652 @default.
• W2490734223 creator A5028579545 @default.
• W2490734223 creator A5034555749 @default.
• W2490734223 creator A5035209924 @default.
• W2490734223 creator A5043409894 @default.
• W2490734223 creator A5050493192 @default.
• W2490734223 creator A5055994027 @default.
• W2490734223 creator A5069228108 @default.
• W2490734223 creator A5077259003 @default.
• W2490734223 creator A5080609124 @default.
• W2490734223 date "2016-07-29" @default.
• W2490734223 modified "2023-09-25" @default.
• W2490734223 title "Nitidine chloride inhibits proliferation, induces apoptosis via the Akt pathway and exhibits a synergistic effect with doxorubicin in ovarian cancer cells" @default.
• W2490734223 cites W1522731616 @default.
• W2490734223 cites W1908956228 @default.
• W2490734223 cites W1980643223 @default.
• W2490734223 cites W1980892224 @default.
• W2490734223 cites W1982254489 @default.
• W2490734223 cites W1989600682 @default.
• W2490734223 cites W1989646379 @default.
• W2490734223 cites W1991376100 @default.
• W2490734223 cites W2002801265 @default.
• W2490734223 cites W2016347688 @default.
• W2490734223 cites W2023560849 @default.
• W2490734223 cites W2026367694 @default.
• W2490734223 cites W2028946225 @default.
• W2490734223 cites W2032397771 @default.
• W2490734223 cites W2055361229 @default.
• W2490734223 cites W2057359246 @default.
• W2490734223 cites W2062880437 @default.
• W2490734223 cites W2075711878 @default.
• W2490734223 cites W2079387868 @default.
• W2490734223 cites W2084304742 @default.
• W2490734223 cites W2085728531 @default.
• W2490734223 cites W2087174559 @default.
• W2490734223 cites W2106787323 @default.
• W2490734223 cites W2107409837 @default.
• W2490734223 cites W2138819828 @default.
• W2490734223 cites W2147114673 @default.
• W2490734223 cites W2150048195 @default.
• W2490734223 cites W2152020818 @default.
• W2490734223 cites W2169961966 @default.
• W2490734223 cites W2259568108 @default.
• W2490734223 doi "https://doi.org/10.3892/mmr.2016.5577" @default.
• W2490734223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27485415" @default.
• W2490734223 hasPublicationYear "2016" @default.
• W2490734223 type Work @default.
• W2490734223 sameAs 2490734223 @default.
• W2490734223 citedByCount "15" @default.
• W2490734223 countsByYear W24907342232017 @default.
• W2490734223 countsByYear W24907342232018 @default.
• W2490734223 countsByYear W24907342232019 @default.
• W2490734223 countsByYear W24907342232020 @default.
• W2490734223 countsByYear W24907342232022 @default.
• W2490734223 crossrefType "journal-article" @default.
• W2490734223 hasAuthorship W2490734223A5003738753 @default.
• W2490734223 hasAuthorship W2490734223A5006159092 @default.
• W2490734223 hasAuthorship W2490734223A5007433652 @default.
• W2490734223 hasAuthorship W2490734223A5028579545 @default.
• W2490734223 hasAuthorship W2490734223A5034555749 @default.
• W2490734223 hasAuthorship W2490734223A5035209924 @default.
• W2490734223 hasAuthorship W2490734223A5043409894 @default.
• W2490734223 hasAuthorship W2490734223A5050493192 @default.
• W2490734223 hasAuthorship W2490734223A5055994027 @default.
• W2490734223 hasAuthorship W2490734223A5069228108 @default.
• W2490734223 hasAuthorship W2490734223A5077259003 @default.
• W2490734223 hasAuthorship W2490734223A5080609124 @default.
• W2490734223 hasBestOaLocation W24907342231 @default.
• W2490734223 hasConcept C121608353 @default.
• W2490734223 hasConcept C153911025 @default.
• W2490734223 hasConcept C185592680 @default.
• W2490734223 hasConcept C190283241 @default.
• W2490734223 hasConcept C2776912716 @default.
• W2490734223 hasConcept C2780427987 @default.
• W2490734223 hasConcept C2781018059 @default.
• W2490734223 hasConcept C29537977 @default.
• W2490734223 hasConcept C502942594 @default.
• W2490734223 hasConcept C53227056 @default.
• W2490734223 hasConcept C54355233 @default.
• W2490734223 hasConcept C55493867 @default.
• W2490734223 hasConcept C62112901 @default.
• W2490734223 hasConcept C75217442 @default.
• W2490734223 hasConcept C86554907 @default.
• W2490734223 hasConcept C86803240 @default.
• W2490734223 hasConcept C96232424 @default.
• W2490734223 hasConceptScore W2490734223C121608353 @default.
• W2490734223 hasConceptScore W2490734223C153911025 @default.
• W2490734223 hasConceptScore W2490734223C185592680 @default.
• W2490734223 hasConceptScore W2490734223C190283241 @default.
• W2490734223 hasConceptScore W2490734223C2776912716 @default.
• W2490734223 hasConceptScore W2490734223C2780427987 @default.
• W2490734223 hasConceptScore W2490734223C2781018059 @default.
• W2490734223 hasConceptScore W2490734223C29537977 @default.
• W2490734223 hasConceptScore W2490734223C502942594 @default.

• next