Matches in SemOpenAlex for { <https://semopenalex.org/work/W2490849148> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2490849148 endingPage "1579" @default.
- W2490849148 startingPage "1579" @default.
- W2490849148 abstract "1579 Background: The aims were to identify the overall incidence and risk of developing a met-TGCT, and compare the risk between patients treated before and after 1980 (cisplatinum-based chemotherapy became available for newly diagnosed TGCT patients in Norway). Our hypothesis was that the risk of TCGT would be reduced for patients diagnosed after 1980, at least for subgroups of patients, due to a protective effect of cisplatinum. Methods: The study included 7,248 men with unilateral TGCT (seminoma: 3,999, nonseminoma: 3,249) recorded in the Cancer Registry of Norway. Allowing for competing risk, 10- and 20-year cumulative incidence (cum. inc.) and adjusted hazard ratios (HR) were estimated for different subgroups, and the diagnostic periods 1953-1979 (I) and 1980-2007 (II). After 1980, 20-25% of all men (1987) with initially localized TGCT, and nearly all men (570) with metastatic TGCT, received cisplatinum. Results: 175 men were diagnosed with met-TGCT. Period I: 38 met-TGCT, 10- and 20-year cumulative incidence 1.3% (0.9-1.9) and 1.9% (1.4-2.6). Period II: 137 met-TGCT, 10- and 20-year cumulative incidence 2.7% (2.2-3.2) and 3.9% (3.3-4.7). Conclusions: Comparing the two periods, there has been a two-fold increase in the incidence of unilateral TGCT, and the cumulative incidence of met-TGCT has doubled. Increasing age reduced the risk in both periods, but more so in period I. In period II, the risk of met-TGCT was halved for patients with metastatic disease compared to patients with localized disease, whereas the protective effect of extent of disease lacked significance for period I. These findings support our hypothesis that cisplatinum reduced the risk of TGCT for patients diagnosed after 1980, at least for those with metastatic TGCT. First TGCC: 1953-1979 1980-2007 10-year cum.inc. Comp.risk reg. 10-year cum.inc. Comp.risk reg. % 95%CI HR 95%CI % 95%CI HR 95%CI Age < 30 years 2.7 1.6-4.2 Ref 3.7 2.8-4.7 Ref ≥30 years 0.7 0.4-1.3 0.2 0.1-0.4 2.0 1.5-2.6 0.5 0.3-0.7 Histology Seminoma 1.2 0.7-2.0 Ref 1.5 0.8-2.6 Ref Nonseminoma 2.8 2.2-3.6 0.8 0.4-1.8 2.5 1.9-3.3 0.9 0.6-1.2 Extent of disease Localized 1.3 0.8-2.1 Ref 3.2 2.6-4.0 Ref Metastatic 1.4 0.7-2.6 0.7 0.3-1.4 1.6 1.0-2.4 0.5 0.3-0.8 No significant financial relationships to disclose." @default.
- W2490849148 created "2016-08-23" @default.
- W2490849148 creator A5017952380 @default.
- W2490849148 creator A5043004401 @default.
- W2490849148 creator A5060786167 @default.
- W2490849148 creator A5067530275 @default.
- W2490849148 creator A5073409303 @default.
- W2490849148 date "2010-05-20" @default.
- W2490849148 modified "2023-09-26" @default.
- W2490849148 title "Risk of metachronous contralateral testicular germ cell tumor (met-TGCT) among 7,248 Norwegian patients (1953-2007)." @default.
- W2490849148 doi "https://doi.org/10.1200/jco.2010.28.15_suppl.1579" @default.
- W2490849148 hasPublicationYear "2010" @default.
- W2490849148 type Work @default.
- W2490849148 sameAs 2490849148 @default.
- W2490849148 citedByCount "0" @default.
- W2490849148 crossrefType "journal-article" @default.
- W2490849148 hasAuthorship W2490849148A5017952380 @default.
- W2490849148 hasAuthorship W2490849148A5043004401 @default.
- W2490849148 hasAuthorship W2490849148A5060786167 @default.
- W2490849148 hasAuthorship W2490849148A5067530275 @default.
- W2490849148 hasAuthorship W2490849148A5073409303 @default.
- W2490849148 hasConcept C120665830 @default.
- W2490849148 hasConcept C121332964 @default.
- W2490849148 hasConcept C121608353 @default.
- W2490849148 hasConcept C126322002 @default.
- W2490849148 hasConcept C143998085 @default.
- W2490849148 hasConcept C151032500 @default.
- W2490849148 hasConcept C207103383 @default.
- W2490849148 hasConcept C2776212926 @default.
- W2490849148 hasConcept C2776694085 @default.
- W2490849148 hasConcept C2778074268 @default.
- W2490849148 hasConcept C2911180711 @default.
- W2490849148 hasConcept C29456083 @default.
- W2490849148 hasConcept C2994039464 @default.
- W2490849148 hasConcept C44249647 @default.
- W2490849148 hasConcept C61511704 @default.
- W2490849148 hasConcept C71924100 @default.
- W2490849148 hasConcept C72563966 @default.
- W2490849148 hasConcept C88879693 @default.
- W2490849148 hasConceptScore W2490849148C120665830 @default.
- W2490849148 hasConceptScore W2490849148C121332964 @default.
- W2490849148 hasConceptScore W2490849148C121608353 @default.
- W2490849148 hasConceptScore W2490849148C126322002 @default.
- W2490849148 hasConceptScore W2490849148C143998085 @default.
- W2490849148 hasConceptScore W2490849148C151032500 @default.
- W2490849148 hasConceptScore W2490849148C207103383 @default.
- W2490849148 hasConceptScore W2490849148C2776212926 @default.
- W2490849148 hasConceptScore W2490849148C2776694085 @default.
- W2490849148 hasConceptScore W2490849148C2778074268 @default.
- W2490849148 hasConceptScore W2490849148C2911180711 @default.
- W2490849148 hasConceptScore W2490849148C29456083 @default.
- W2490849148 hasConceptScore W2490849148C2994039464 @default.
- W2490849148 hasConceptScore W2490849148C44249647 @default.
- W2490849148 hasConceptScore W2490849148C61511704 @default.
- W2490849148 hasConceptScore W2490849148C71924100 @default.
- W2490849148 hasConceptScore W2490849148C72563966 @default.
- W2490849148 hasConceptScore W2490849148C88879693 @default.
- W2490849148 hasIssue "15_suppl" @default.
- W2490849148 hasLocation W24908491481 @default.
- W2490849148 hasOpenAccess W2490849148 @default.
- W2490849148 hasPrimaryLocation W24908491481 @default.
- W2490849148 hasRelatedWork W1902616231 @default.
- W2490849148 hasRelatedWork W1968364149 @default.
- W2490849148 hasRelatedWork W2072085089 @default.
- W2490849148 hasRelatedWork W2172304980 @default.
- W2490849148 hasRelatedWork W2410253477 @default.
- W2490849148 hasRelatedWork W2490849148 @default.
- W2490849148 hasRelatedWork W3007896559 @default.
- W2490849148 hasRelatedWork W4224443899 @default.
- W2490849148 hasRelatedWork W4232906502 @default.
- W2490849148 hasRelatedWork W2517932925 @default.
- W2490849148 hasVolume "28" @default.
- W2490849148 isParatext "false" @default.
- W2490849148 isRetracted "false" @default.
- W2490849148 magId "2490849148" @default.
- W2490849148 workType "article" @default.