Matches in SemOpenAlex for { <https://semopenalex.org/work/W2491222500> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2491222500 endingPage "52" @default.
- W2491222500 startingPage "52" @default.
- W2491222500 abstract "PURPOSE: Insulin and branched-chain amino acids (BCAA) are two potent stimuli among plasma circulating factors in enhancing muscle protein anabolism. However, little is known whether either BCAA alone or BCAA+insulin enhance muscle protein metabolism in humans. METHODS: Seven healthy young subjects (gender, 4M/3F; age, 19±1 years; BMI, 23±1) were infused with BCAA (5 umol/kg/min) for six hours (BCAA) and insulin [either 40 mu/m2/min (n=3) or 80 mu/m2/min (n=4)] during the last three hours of the BCAA infusion. Another seven (gender, 6M/1F; age, 23±2 years; BMI, 23±1) underwent the same protocol but with saline instead of BCAA infusion (Saline). The effects of BCAA on muscle protein synthesis and whole-body protein breakdown, an indirect estimate of muscle protein breakdown, were studied between BCAA and Saline groups, while those of insulin within each group, and in conjunction with continuous infusion of L-[ring-2H5]phenylalanine and muscle biopsies at selected time points. RESULTS: There were no differences between BCAA and Saline groups in the fractional synthesis rate (FSR; %/h) of muscle proteins before the insulin infusion (0.06±0.02 vs 0.05±0.01; P>0.05). Insulin infusion did not increase the FSR within either BCAA (0.06±0.02 vs 0.05±0.01; P>0.05) or Saline (0.05±0.01vs 0.06±0.01; P>0.05) groups. However, whole-body protein breakdown (umol/kg/min) tended to be lower in the BCAA vs Saline group (0.97±0.07 vs 1.10±0.05; P=0.09), and decreased following the insulin infusion within both BCAA (0.97±0.07 vs .67±0.3; P<0.01) and Saline (1.10±0.05 vs 0.83±0.03; P<0.01) groups, with a significantly greater effect between groups during insulin (P<0.01). Insulin infusion decreased the concentration of plasma total as well as non-BCAA essential amino acid concentrations in both BCAA and Saline (P<0.05) with no differences between groups (P>0.05). CONCLUSIONS: These findings show that the effects of BCAA are augmented by insulin, resulting in suppressed muscle protein breakdown with no changes in muscle protein synthesis." @default.
- W2491222500 created "2016-08-23" @default.
- W2491222500 creator A5007704729 @default.
- W2491222500 creator A5046777440 @default.
- W2491222500 creator A5055582386 @default.
- W2491222500 creator A5062639239 @default.
- W2491222500 creator A5065742652 @default.
- W2491222500 creator A5074138380 @default.
- W2491222500 date "2016-05-01" @default.
- W2491222500 modified "2023-10-18" @default.
- W2491222500 title "Effects of Increased Plasma Branched-chain Amino Acids and Insulin on Muscle Protein Metabolism" @default.
- W2491222500 doi "https://doi.org/10.1249/01.mss.0000485166.55228.f0" @default.
- W2491222500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27359490" @default.
- W2491222500 hasPublicationYear "2016" @default.
- W2491222500 type Work @default.
- W2491222500 sameAs 2491222500 @default.
- W2491222500 citedByCount "0" @default.
- W2491222500 crossrefType "journal-article" @default.
- W2491222500 hasAuthorship W2491222500A5007704729 @default.
- W2491222500 hasAuthorship W2491222500A5046777440 @default.
- W2491222500 hasAuthorship W2491222500A5055582386 @default.
- W2491222500 hasAuthorship W2491222500A5062639239 @default.
- W2491222500 hasAuthorship W2491222500A5065742652 @default.
- W2491222500 hasAuthorship W2491222500A5074138380 @default.
- W2491222500 hasConcept C1008401 @default.
- W2491222500 hasConcept C126322002 @default.
- W2491222500 hasConcept C134018914 @default.
- W2491222500 hasConcept C185592680 @default.
- W2491222500 hasConcept C197683979 @default.
- W2491222500 hasConcept C2776580952 @default.
- W2491222500 hasConcept C2777397205 @default.
- W2491222500 hasConcept C2777431362 @default.
- W2491222500 hasConcept C2779306644 @default.
- W2491222500 hasConcept C2779572773 @default.
- W2491222500 hasConcept C2779959927 @default.
- W2491222500 hasConcept C2780677274 @default.
- W2491222500 hasConcept C3019971869 @default.
- W2491222500 hasConcept C515207424 @default.
- W2491222500 hasConcept C55493867 @default.
- W2491222500 hasConcept C62231903 @default.
- W2491222500 hasConcept C71924100 @default.
- W2491222500 hasConcept C86803240 @default.
- W2491222500 hasConceptScore W2491222500C1008401 @default.
- W2491222500 hasConceptScore W2491222500C126322002 @default.
- W2491222500 hasConceptScore W2491222500C134018914 @default.
- W2491222500 hasConceptScore W2491222500C185592680 @default.
- W2491222500 hasConceptScore W2491222500C197683979 @default.
- W2491222500 hasConceptScore W2491222500C2776580952 @default.
- W2491222500 hasConceptScore W2491222500C2777397205 @default.
- W2491222500 hasConceptScore W2491222500C2777431362 @default.
- W2491222500 hasConceptScore W2491222500C2779306644 @default.
- W2491222500 hasConceptScore W2491222500C2779572773 @default.
- W2491222500 hasConceptScore W2491222500C2779959927 @default.
- W2491222500 hasConceptScore W2491222500C2780677274 @default.
- W2491222500 hasConceptScore W2491222500C3019971869 @default.
- W2491222500 hasConceptScore W2491222500C515207424 @default.
- W2491222500 hasConceptScore W2491222500C55493867 @default.
- W2491222500 hasConceptScore W2491222500C62231903 @default.
- W2491222500 hasConceptScore W2491222500C71924100 @default.
- W2491222500 hasConceptScore W2491222500C86803240 @default.
- W2491222500 hasLocation W24912225001 @default.
- W2491222500 hasOpenAccess W2491222500 @default.
- W2491222500 hasPrimaryLocation W24912225001 @default.
- W2491222500 hasRelatedWork W1967622538 @default.
- W2491222500 hasRelatedWork W1982685226 @default.
- W2491222500 hasRelatedWork W1991453182 @default.
- W2491222500 hasRelatedWork W1992523552 @default.
- W2491222500 hasRelatedWork W2028764585 @default.
- W2491222500 hasRelatedWork W2032110122 @default.
- W2491222500 hasRelatedWork W2096487945 @default.
- W2491222500 hasRelatedWork W2127461276 @default.
- W2491222500 hasRelatedWork W2128583851 @default.
- W2491222500 hasRelatedWork W2149833349 @default.
- W2491222500 hasVolume "48" @default.
- W2491222500 isParatext "false" @default.
- W2491222500 isRetracted "false" @default.
- W2491222500 magId "2491222500" @default.
- W2491222500 workType "article" @default.