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• W2491244218 startingPage "26" @default.
• W2491244218 abstract "Background: Transcranial direct current stimulation (tDCS) is emerging as a promising adjuvant to enhance motor function. However, there has been increasing reservations about the reliability and variability of the neuromodulatory effects evoked by tDCS. Objective/Hypothesis: The main purpose of this study was to explore the test-retest reliability and inter-individual variability of tDCS of the lower limb M1 and the relationship between transcranial magnetic stimulation (TMS)-related measures and tDCS-induced changes. Methods: Fifteen healthy participants received anodal tDCS of the lower limb M1 either when performing a lower limb motor task or when the limb was at rest. Each condition was tested twice. tDCS induced changes in corticomotor excitability of the tibialis anterior muscle were measured using TMS. A repeated measures ANOVA was performed to examine efficacy of tDCS between the two task conditions. Intraclass correlation coefficients (ICC) and variance component analyses were performed to examine reliability and variability respectively. Results: A significant increase in in corticomotor excitability was noted for the tDCS-task condition at 140% active motor threshold (AMT) and when comparing recruitment curve slopes, but not at 120% and 130% AMT. Overall, ICC values between testing days for each stimulation condition ranged from 0.6–0.9. Higher ICCs were seen for higher TMS intensities (140% AMT) and recruitment curve slopes. Inter-individual variability contributed to 34% of the exhibited variance. Conclusions: Our data suggest that the TMS-related measure used to assess neuromodulation after tDCS has an effect on its perceived test-retest reliability and inter-individual variability. Importantly, we noticed that a high reliability and low variability does not necessarily indicate clinical efficacy of tDCS as some participants showed little to no modulation of corticomotor excitability consistently." @default.
• W2491244218 created "2016-08-23" @default.
• W2491244218 creator A5000927535 @default.
• W2491244218 creator A5031519591 @default.
• W2491244218 creator A5033055086 @default.
• W2491244218 date "2016-07-27" @default.
• W2491244218 modified "2023-10-16" @default.
• W2491244218 title "Reliability and Variability of tDCS Induced Changes in the Lower Limb Motor Cortex" @default.
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• W2491244218 doi "https://doi.org/10.3390/brainsci6030026" @default.
• W2491244218 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5039455" @default.
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