Matches in SemOpenAlex for { <https://semopenalex.org/work/W2491263595> ?p ?o ?g. }
- W2491263595 endingPage "21256" @default.
- W2491263595 startingPage "21246" @default.
- W2491263595 abstract "The replication protein A (RPA) is a single-stranded DNA-binding protein that plays an essential role in DNA metabolism. RPA is able to unfold G-quadruplex (G4) structures formed by telomeric DNA sequences, a function important for telomere maintenance. To elucidate the mechanism through which RPA unfolds telomeric G4s, we studied its interaction with oligonucleotides that adopt a G4 structure extended with a single-stranded tail on either side of the G4. Binding and unfolding was characterized using several biochemical and biophysical approaches and in the presence of specific G4 ligands, such as telomestatin and 360A. Our data show that RPA can bind on each side of the G4 but it unwinds the G4 only from 5′ toward 3′. We explain the 5′ to 3′ unfolding directionality in terms of the 5′ to 3′ oriented laying out of hRPA subunits along single-stranded DNA. Furthermore, we demonstrate by kinetics experiments that RPA proceeds with the same directionality for duplex unfolding." @default.
- W2491263595 created "2016-08-23" @default.
- W2491263595 creator A5001007906 @default.
- W2491263595 creator A5017682764 @default.
- W2491263595 creator A5032790213 @default.
- W2491263595 creator A5050735556 @default.
- W2491263595 creator A5059626752 @default.
- W2491263595 creator A5060981364 @default.
- W2491263595 creator A5062753170 @default.
- W2491263595 creator A5068418438 @default.
- W2491263595 creator A5072431167 @default.
- W2491263595 creator A5081421047 @default.
- W2491263595 creator A5088573814 @default.
- W2491263595 date "2016-09-01" @default.
- W2491263595 modified "2023-10-16" @default.
- W2491263595 title "5′ to 3′ Unfolding Directionality of DNA Secondary Structures by Replication Protein A" @default.
- W2491263595 cites W1523125680 @default.
- W2491263595 cites W1585519565 @default.
- W2491263595 cites W193545315 @default.
- W2491263595 cites W1967319246 @default.
- W2491263595 cites W1969436803 @default.
- W2491263595 cites W1974481952 @default.
- W2491263595 cites W1976291456 @default.
- W2491263595 cites W1977602663 @default.
- W2491263595 cites W1980681058 @default.
- W2491263595 cites W1981373869 @default.
- W2491263595 cites W1984376253 @default.
- W2491263595 cites W1988780940 @default.
- W2491263595 cites W1997649177 @default.
- W2491263595 cites W2000409041 @default.
- W2491263595 cites W2006818688 @default.
- W2491263595 cites W2008871447 @default.
- W2491263595 cites W2013588275 @default.
- W2491263595 cites W2015078392 @default.
- W2491263595 cites W2017032602 @default.
- W2491263595 cites W2020355721 @default.
- W2491263595 cites W2026370504 @default.
- W2491263595 cites W2027657574 @default.
- W2491263595 cites W2033669448 @default.
- W2491263595 cites W2037218397 @default.
- W2491263595 cites W2042278282 @default.
- W2491263595 cites W2042931953 @default.
- W2491263595 cites W2052460325 @default.
- W2491263595 cites W2053166926 @default.
- W2491263595 cites W2056201880 @default.
- W2491263595 cites W2058384455 @default.
- W2491263595 cites W2059355381 @default.
- W2491263595 cites W2065652369 @default.
- W2491263595 cites W2076154132 @default.
- W2491263595 cites W2078024052 @default.
- W2491263595 cites W2083265327 @default.
- W2491263595 cites W2090573596 @default.
- W2491263595 cites W2092324565 @default.
- W2491263595 cites W2093320042 @default.
- W2491263595 cites W2093395725 @default.
- W2491263595 cites W2100516380 @default.
- W2491263595 cites W2104881338 @default.
- W2491263595 cites W2121193576 @default.
- W2491263595 cites W2123527421 @default.
- W2491263595 cites W2134240223 @default.
- W2491263595 cites W2135003636 @default.
- W2491263595 cites W2137026987 @default.
- W2491263595 cites W2140590042 @default.
- W2491263595 cites W2144171881 @default.
- W2491263595 cites W2148772646 @default.
- W2491263595 cites W2155773930 @default.
- W2491263595 cites W2156206373 @default.
- W2491263595 cites W2157811245 @default.
- W2491263595 cites W2163548075 @default.
- W2491263595 cites W2171775098 @default.
- W2491263595 cites W2269237057 @default.
- W2491263595 cites W2317960638 @default.
- W2491263595 cites W2337552281 @default.
- W2491263595 doi "https://doi.org/10.1074/jbc.m115.709667" @default.
- W2491263595 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5076531" @default.
- W2491263595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27440048" @default.
- W2491263595 hasPublicationYear "2016" @default.
- W2491263595 type Work @default.
- W2491263595 sameAs 2491263595 @default.
- W2491263595 citedByCount "36" @default.
- W2491263595 countsByYear W24912635952017 @default.
- W2491263595 countsByYear W24912635952018 @default.
- W2491263595 countsByYear W24912635952019 @default.
- W2491263595 countsByYear W24912635952020 @default.
- W2491263595 countsByYear W24912635952021 @default.
- W2491263595 countsByYear W24912635952022 @default.
- W2491263595 countsByYear W24912635952023 @default.
- W2491263595 crossrefType "journal-article" @default.
- W2491263595 hasAuthorship W2491263595A5001007906 @default.
- W2491263595 hasAuthorship W2491263595A5017682764 @default.
- W2491263595 hasAuthorship W2491263595A5032790213 @default.
- W2491263595 hasAuthorship W2491263595A5050735556 @default.
- W2491263595 hasAuthorship W2491263595A5059626752 @default.
- W2491263595 hasAuthorship W2491263595A5060981364 @default.
- W2491263595 hasAuthorship W2491263595A5062753170 @default.
- W2491263595 hasAuthorship W2491263595A5068418438 @default.
- W2491263595 hasAuthorship W2491263595A5072431167 @default.
- W2491263595 hasAuthorship W2491263595A5081421047 @default.