FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2491285460> ?p ?o ?g. }

• W2491285460 abstract "Relative to other types of drug delivery formulations, pulmonary drug delivery systems have used only a small number of excipients. However, the field is rapidly expanding and the need for alternatives has been realized. Two peaks in patent filings have been identified over the last 30 years (1), both related to the findings by Molina and Rowland (2), which implicated chlorofluorocarbons (CFCs) in the depletion of stratospheric ozone. It became clear that the propellants used in metered dose inhalers (MDIs), the most common device used for administering therapeutic aerosols, would need phasing out and replacement by non–ozone depleting alternatives. Although this transition has largely taken place, the number of excipients available for formulators to use in inhalation aerosol products remains low. Traditionally, inhaled therapeutics have been primarily employed for the treatment and prevention of local respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). From this perspective, the treatment of local lung diseases by using an aerosol has key advantages over other routes of administration, including targeting the site of the disease, lowered plasma concentrations, decreased systemic side effects, and rapid onset of action. More recently, the airways have also been viewed with increasing anticipation as a possible route for the administration of a wide range of systemically acting compounds, including protein and peptide therapeutics (3). It is widely anticipated that technologies for aerosol administration of insulin in the treatment of insulin-dependent diabetes mellitus will come into fruition in the near future (4). The expansion of the number of therapeutic compounds and candidate molecules for administration to the lung will undoubtedly lead to a parallel expansion in the number of excipients that will be included in approved and marketed products. Accordingly, the scientific literature and patent databases provide evidence of significant work in this area. However, aerosol administration to the lungs is not without limitations. For formulators and process engineers, pharmaceutical inhalation aerosols have been relatively difficult to develop" @default.
• W2491285460 created "2016-08-23" @default.
• W2491285460 creator A5036361468 @default.
• W2491285460 date "2006-07-28" @default.
• W2491285460 modified "2023-09-23" @default.
• W2491285460 title "Excipients for Pulmonary Formulations" @default.
• W2491285460 cites W129419657 @default.
• W2491285460 cites W1511036913 @default.
• W2491285460 cites W1555994455 @default.
• W2491285460 cites W1581858536 @default.
• W2491285460 cites W1607515676 @default.
• W2491285460 cites W1644145415 @default.
• W2491285460 cites W1964163557 @default.
• W2491285460 cites W1968328406 @default.
• W2491285460 cites W1969266865 @default.
• W2491285460 cites W1969473135 @default.
• W2491285460 cites W1973201004 @default.
• W2491285460 cites W1976659194 @default.
• W2491285460 cites W1980323335 @default.
• W2491285460 cites W1986186916 @default.
• W2491285460 cites W1991134831 @default.
• W2491285460 cites W1991902254 @default.
• W2491285460 cites W1992338307 @default.
• W2491285460 cites W1993838495 @default.
• W2491285460 cites W1999944868 @default.
• W2491285460 cites W2002930286 @default.
• W2491285460 cites W2004460130 @default.
• W2491285460 cites W2019378633 @default.
• W2491285460 cites W2019785811 @default.
• W2491285460 cites W2022069744 @default.
• W2491285460 cites W2027417441 @default.
• W2491285460 cites W2034685546 @default.
• W2491285460 cites W2035370909 @default.
• W2491285460 cites W2037106471 @default.
• W2491285460 cites W2037987103 @default.
• W2491285460 cites W2043797786 @default.
• W2491285460 cites W2045467856 @default.
• W2491285460 cites W2046516716 @default.
• W2491285460 cites W2055506966 @default.
• W2491285460 cites W2058075027 @default.
• W2491285460 cites W2058179313 @default.
• W2491285460 cites W2060249949 @default.
• W2491285460 cites W2062820214 @default.
• W2491285460 cites W2064303047 @default.
• W2491285460 cites W2067242600 @default.
• W2491285460 cites W2068805835 @default.
• W2491285460 cites W2070823215 @default.
• W2491285460 cites W2073470094 @default.
• W2491285460 cites W2073909399 @default.
• W2491285460 cites W2081441319 @default.
• W2491285460 cites W2082203116 @default.
• W2491285460 cites W2086649068 @default.
• W2491285460 cites W2092886084 @default.
• W2491285460 cites W2095417469 @default.
• W2491285460 cites W2095682923 @default.
• W2491285460 cites W209799331 @default.
• W2491285460 cites W2099869416 @default.
• W2491285460 cites W2101883647 @default.
• W2491285460 cites W2108690975 @default.
• W2491285460 cites W2109760476 @default.
• W2491285460 cites W2122216165 @default.
• W2491285460 cites W2128662846 @default.
• W2491285460 cites W2173489425 @default.
• W2491285460 cites W2181723254 @default.
• W2491285460 cites W2212029653 @default.
• W2491285460 cites W2293060834 @default.
• W2491285460 cites W2394937423 @default.
• W2491285460 cites W2480217345 @default.
• W2491285460 cites W2480938800 @default.
• W2491285460 cites W2493656234 @default.
• W2491285460 cites W2494977633 @default.
• W2491285460 cites W2501862345 @default.
• W2491285460 cites W2788674711 @default.
• W2491285460 cites W2797587591 @default.
• W2491285460 cites W2949619635 @default.
• W2491285460 cites W64594346 @default.
• W2491285460 cites W2401207030 @default.
• W2491285460 cites W2471160628 @default.
• W2491285460 cites W2745492731 @default.
• W2491285460 cites W2972277661 @default.
• W2491285460 cites W3134608094 @default.
• W2491285460 doi "https://doi.org/10.1201/9781420004137-17" @default.
• W2491285460 hasPublicationYear "2006" @default.
• W2491285460 type Work @default.
• W2491285460 sameAs 2491285460 @default.
• W2491285460 citedByCount "2" @default.
• W2491285460 countsByYear W24912854602012 @default.
• W2491285460 countsByYear W24912854602017 @default.
• W2491285460 crossrefType "book-chapter" @default.
• W2491285460 hasAuthorship W2491285460A5036361468 @default.
• W2491285460 hasConcept C126322002 @default.
• W2491285460 hasConcept C177713679 @default.
• W2491285460 hasConcept C203014093 @default.
• W2491285460 hasConcept C2776042228 @default.
• W2491285460 hasConcept C2776780178 @default.
• W2491285460 hasConcept C2780035454 @default.
• W2491285460 hasConcept C2992779976 @default.
• W2491285460 hasConcept C71924100 @default.
• W2491285460 hasConcept C98274493 @default.
• W2491285460 hasConceptScore W2491285460C126322002 @default.

• next