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- W2491314947 abstract "This chapter discusses studies analyzing immunosuppression by tumor viruses, and the effects of leukemia virus infection on the immune response. In one study, mice infected with friend virus (FV) at different times, either prior to, simultaneously with, or after challenge immunization with sheep erythrocytes, showed varying levels of immunologic responsiveness. The fewest antibody plaque-forming cells (PFC) to the erythrocytes occurred in mice infected with virus prior to immunization. Maximum suppression occurred when the interval between infection and immunity was the longest. Both the primary and secondary responses were depressed when mice were infected with virus 3–8 days or longer before challenge immunization. Although both 7S (IgG) and 19S (IgM) PFCs were affected during the secondary response, the greatest depression occurred in the number of low-efficiency 7S PFCs. The degree of suppression was also directly related to the dose of virus administered. A greater level of immunosuppression occurred with the most concentrated dose of virus. Splenomegaly of infected animals appeared to be related to the level of immunosuppression." @default.
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- W2491314947 date "1971-01-01" @default.
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- W2491314947 title "Immunosuppression by Tumor Viruses: Effects of Leukemia Virus Infection on the Immune Response**Some of the studies described here were supported by research grants from the U. S. National Science Foundation, the American Cancer Society, and the Damon Runyon Cancer Fund." @default.
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- W2491314947 doi "https://doi.org/10.1016/b978-0-12-057550-3.50066-1" @default.
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