Matches in SemOpenAlex for { <https://semopenalex.org/work/W2491446616> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2491446616 endingPage "515" @default.
- W2491446616 startingPage "513" @default.
- W2491446616 abstract "Publisher SummaryThe genetic basis of leukemia was considered shortly after its definition as a clinical entity, in the middle of the nineteenth century. Indeed, scientists studying human cells had repeatedly counted 46 chromosomes, but discarded the results assuming their technique was faulty. In the course of these studies, they noted the presence of a minute chromosome in the cells from two patients with chronic myelogenous leukemia. This protein, a phosphotyrosine kinase, phosphorylates tyrosine residues on proteins in an unregulated manner and is the seminal factor in the transformation of the pluripotential hematopoietic stem cell into a malignant cell. The demonstration of the nature of this translocation highlighted the power given to cytogeneticists by banding techniques to more precisely characterize the chromosome alterations in human cancers, especially leukemias and lymphomas. In most of the cases, cells with normal chromosomes were also observed. Thus, the minute chromosome is not a part of the normal chromosome constitution of such individuals. The findings suggest a causal relationship between the chromosome abnormality observed and chronic granulocytic leukemia." @default.
- W2491446616 created "2016-08-23" @default.
- W2491446616 creator A5017159299 @default.
- W2491446616 creator A5022401670 @default.
- W2491446616 creator A5032031578 @default.
- W2491446616 creator A5060459487 @default.
- W2491446616 creator A5081518328 @default.
- W2491446616 date "2000-01-01" @default.
- W2491446616 modified "2023-10-16" @default.
- W2491446616 title "Commentary on and reprint of Nowell PC, Hungerford DA, A minute chromosome in human chronic granulocytic leukemia, in Science (1960) 132:1497" @default.
- W2491446616 doi "https://doi.org/10.1016/b978-012448510-5/50134-5" @default.
- W2491446616 hasPublicationYear "2000" @default.
- W2491446616 type Work @default.
- W2491446616 sameAs 2491446616 @default.
- W2491446616 citedByCount "78" @default.
- W2491446616 countsByYear W24914466162012 @default.
- W2491446616 countsByYear W24914466162013 @default.
- W2491446616 countsByYear W24914466162014 @default.
- W2491446616 countsByYear W24914466162015 @default.
- W2491446616 countsByYear W24914466162016 @default.
- W2491446616 countsByYear W24914466162017 @default.
- W2491446616 countsByYear W24914466162018 @default.
- W2491446616 crossrefType "book-chapter" @default.
- W2491446616 hasAuthorship W2491446616A5017159299 @default.
- W2491446616 hasAuthorship W2491446616A5022401670 @default.
- W2491446616 hasAuthorship W2491446616A5032031578 @default.
- W2491446616 hasAuthorship W2491446616A5060459487 @default.
- W2491446616 hasAuthorship W2491446616A5081518328 @default.
- W2491446616 hasConcept C104317684 @default.
- W2491446616 hasConcept C109159458 @default.
- W2491446616 hasConcept C138626823 @default.
- W2491446616 hasConcept C203014093 @default.
- W2491446616 hasConcept C2776960273 @default.
- W2491446616 hasConcept C2778461978 @default.
- W2491446616 hasConcept C2778904597 @default.
- W2491446616 hasConcept C2780189214 @default.
- W2491446616 hasConcept C28328180 @default.
- W2491446616 hasConcept C30481170 @default.
- W2491446616 hasConcept C31033888 @default.
- W2491446616 hasConcept C502942594 @default.
- W2491446616 hasConcept C53226629 @default.
- W2491446616 hasConcept C54355233 @default.
- W2491446616 hasConcept C86803240 @default.
- W2491446616 hasConceptScore W2491446616C104317684 @default.
- W2491446616 hasConceptScore W2491446616C109159458 @default.
- W2491446616 hasConceptScore W2491446616C138626823 @default.
- W2491446616 hasConceptScore W2491446616C203014093 @default.
- W2491446616 hasConceptScore W2491446616C2776960273 @default.
- W2491446616 hasConceptScore W2491446616C2778461978 @default.
- W2491446616 hasConceptScore W2491446616C2778904597 @default.
- W2491446616 hasConceptScore W2491446616C2780189214 @default.
- W2491446616 hasConceptScore W2491446616C28328180 @default.
- W2491446616 hasConceptScore W2491446616C30481170 @default.
- W2491446616 hasConceptScore W2491446616C31033888 @default.
- W2491446616 hasConceptScore W2491446616C502942594 @default.
- W2491446616 hasConceptScore W2491446616C53226629 @default.
- W2491446616 hasConceptScore W2491446616C54355233 @default.
- W2491446616 hasConceptScore W2491446616C86803240 @default.
- W2491446616 hasLocation W24914466161 @default.
- W2491446616 hasOpenAccess W2491446616 @default.
- W2491446616 hasPrimaryLocation W24914466161 @default.
- W2491446616 hasRelatedWork W147310725 @default.
- W2491446616 hasRelatedWork W2007393951 @default.
- W2491446616 hasRelatedWork W2035165731 @default.
- W2491446616 hasRelatedWork W2072343881 @default.
- W2491446616 hasRelatedWork W2093913151 @default.
- W2491446616 hasRelatedWork W2123343600 @default.
- W2491446616 hasRelatedWork W2267423667 @default.
- W2491446616 hasRelatedWork W2281287090 @default.
- W2491446616 hasRelatedWork W4233671041 @default.
- W2491446616 hasRelatedWork W4247513461 @default.
- W2491446616 isParatext "false" @default.
- W2491446616 isRetracted "false" @default.
- W2491446616 magId "2491446616" @default.
- W2491446616 workType "book-chapter" @default.