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- W2491510112 abstract "Pertinent aspects of the chemistry of Ru(II) and Ru(III) complexes are briefly outlined with regard to the utility of these ions in anticancer pharmaceuticals. Of particular interest is that Ru(lII) ammine complexes containing hard ligands may be activated by reduction in vivo to lose the acido groups and subsequently add a nitrogen base, which can then be firmly coordinated to the metal in either oxidation state. Work with nucleosides and mucleic acids indicates that the coordination of Ru(II) to such ligands is similar to that of the Pt(II) anticancer drugs, so that analogous effects might be exerted on nucleic acid metabolism. Ammineruthenium(III) ions, on the other hand, form unusual cytosinato and aderosinato species. Collaborative studies demonstrate that a number of Ru compounds serve as bacterial mutagens, and so indicate that at least some Ru complexes are capable of damaging genetic material. The in vivo production of the more easily substituted" @default.
- W2491510112 created "2016-08-23" @default.
- W2491510112 creator A5011732781 @default.
- W2491510112 date "1980-12-22" @default.
- W2491510112 modified "2023-10-15" @default.
- W2491510112 title "The Potential of Ruthenium in Anticancer Pharmaceuticals" @default.
- W2491510112 doi "https://doi.org/10.1021/bk-1980-0140.ch010" @default.
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