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- W2491538169 abstract "Despite over almost three decades of active research since the discovery of HIV-1 as the infectious agent causing AIDS, an effective vaccine that protects against the virus has not been forthcoming. In this chapter, we begin with a discussion on barriers against eliciting a strong immune response against carbohydrates. We then describe novel technologies arising from the field of glycobiology that are helping researchers overcome them. With that background in place, we move into an introduction on the biochemical structure and biological role of the HIV-1 envelope glycoprotein gp160. We describe how the immune system recognizes it and develop an argument for the application of a carbohydrate vaccine. Analysis of the carbohydrates on gp160 follows leading to detailed descriptions of the high-resolution structures of glycan specific HIV-1 broadly neutralizing antibodies. How these structures inform a new generation of carbohydrate-based HIV-1 vaccines are then discussed in detail." @default.
- W2491538169 created "2016-08-23" @default.
- W2491538169 creator A5005020873 @default.
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- W2491538169 date "2012-01-01" @default.
- W2491538169 modified "2023-10-16" @default.
- W2491538169 title "Toward a Carbohydrate-Based HIV-1 Vaccine" @default.
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