FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2491571917> ?p ?o ?g. }

• W2491571917 endingPage "e2313" @default.
• W2491571917 startingPage "e2313" @default.
• W2491571917 abstract "Cereblon (CRBN) is a substrate receptor protein for the CRL4A E3 ubiquitin ligase complex. In this study, we report on a new regulatory role of CRBN in TLR4 signaling. CRBN overexpression leads to suppression of NF-κB activation and production of pro-inflammatory cytokines including IL-6 and IL-1β in response to TLR4 stimulation. Biochemical studies revealed interactions between CRBN and TAK1, and TRAF6 proteins. The interaction between CRBN and TAK1 did not affect the association of the TAB1 and TAB2 proteins, which have pivotal roles in the activation of TAK1, whereas the CRBN-TRAF6 interaction critically affected ubiquitination of TRAF6 and TAB2. Binding mapping results revealed that CRBN interacts with the Zinc finger domain of TRAF6, which contains the ubiquitination site of TRAF6, leading to attenuation of ubiquitination of TRAF6 and TAB2. Functional studies revealed that CRBN-knockdown THP-1 cells show enhanced NF-κB activation and p65- or p50-DNA binding activities, leading to up-regulation of NF-κB-dependent gene expression and increased pro-inflammatory cytokine levels in response to TLR4 stimulation. Furthermore, Crbn(-/-) mice exhibit decreased survival in response to LPS challenge, accompanied with marked enhancement of pro-inflammatory cytokines, such as TNF-α and IL-6. Taken together, our data demonstrate that CRBN negatively regulates TLR4 signaling via attenuation of TRAF6 and TAB2 ubiquitination." @default.
• W2491571917 created "2016-08-23" @default.
• W2491571917 creator A5004446342 @default.
• W2491571917 creator A5009802113 @default.
• W2491571917 creator A5013808708 @default.
• W2491571917 creator A5031635205 @default.
• W2491571917 creator A5031990323 @default.
• W2491571917 creator A5053795585 @default.
• W2491571917 creator A5058855547 @default.
• W2491571917 creator A5077553920 @default.
• W2491571917 creator A5089876636 @default.
• W2491571917 creator A5090917103 @default.
• W2491571917 date "2016-07-01" @default.
• W2491571917 modified "2023-10-14" @default.
• W2491571917 title "Cereblon negatively regulates TLR4 signaling through the attenuation of ubiquitination of TRAF6" @default.
• W2491571917 cites W1568733499 @default.
• W2491571917 cites W1600472471 @default.
• W2491571917 cites W1619248007 @default.
• W2491571917 cites W1661299775 @default.
• W2491571917 cites W1798108604 @default.
• W2491571917 cites W1968335526 @default.
• W2491571917 cites W1979709316 @default.
• W2491571917 cites W1981397708 @default.
• W2491571917 cites W1985147506 @default.
• W2491571917 cites W1986348227 @default.
• W2491571917 cites W1997952190 @default.
• W2491571917 cites W2005616955 @default.
• W2491571917 cites W2008922065 @default.
• W2491571917 cites W2008955645 @default.
• W2491571917 cites W2010453472 @default.
• W2491571917 cites W2012181651 @default.
• W2491571917 cites W2023100224 @default.
• W2491571917 cites W2024857098 @default.
• W2491571917 cites W2035744389 @default.
• W2491571917 cites W2043801813 @default.
• W2491571917 cites W2046783872 @default.
• W2491571917 cites W2050994851 @default.
• W2491571917 cites W2066713051 @default.
• W2491571917 cites W2074517544 @default.
• W2491571917 cites W2082177829 @default.
• W2491571917 cites W2082861881 @default.
• W2491571917 cites W2085350376 @default.
• W2491571917 cites W2085682466 @default.
• W2491571917 cites W2092206815 @default.
• W2491571917 cites W2093817041 @default.
• W2491571917 cites W2108578752 @default.
• W2491571917 cites W2111165466 @default.
• W2491571917 cites W2115090185 @default.
• W2491571917 cites W2117521332 @default.
• W2491571917 cites W2119601553 @default.
• W2491571917 cites W2120144499 @default.
• W2491571917 cites W2146204355 @default.
• W2491571917 cites W2152602253 @default.
• W2491571917 cites W2156380604 @default.
• W2491571917 cites W2161413435 @default.
• W2491571917 cites W2163623105 @default.
• W2491571917 cites W2165050763 @default.
• W2491571917 cites W2169238760 @default.
• W2491571917 cites W2169348534 @default.
• W2491571917 cites W2257165877 @default.
• W2491571917 cites W2258379561 @default.
• W2491571917 cites W2283442479 @default.
• W2491571917 cites W2316160054 @default.
• W2491571917 cites W2336461395 @default.
• W2491571917 cites W2434407168 @default.
• W2491571917 cites W4230883568 @default.
• W2491571917 cites W4248219898 @default.
• W2491571917 doi "https://doi.org/10.1038/cddis.2016.226" @default.
• W2491571917 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4973362" @default.
• W2491571917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27468689" @default.
• W2491571917 hasPublicationYear "2016" @default.
• W2491571917 type Work @default.
• W2491571917 sameAs 2491571917 @default.
• W2491571917 citedByCount "41" @default.
• W2491571917 countsByYear W24915719172017 @default.
• W2491571917 countsByYear W24915719172018 @default.
• W2491571917 countsByYear W24915719172019 @default.
• W2491571917 countsByYear W24915719172020 @default.
• W2491571917 countsByYear W24915719172021 @default.
• W2491571917 countsByYear W24915719172022 @default.
• W2491571917 countsByYear W24915719172023 @default.
• W2491571917 crossrefType "journal-article" @default.
• W2491571917 hasAuthorship W2491571917A5004446342 @default.
• W2491571917 hasAuthorship W2491571917A5009802113 @default.
• W2491571917 hasAuthorship W2491571917A5013808708 @default.
• W2491571917 hasAuthorship W2491571917A5031635205 @default.
• W2491571917 hasAuthorship W2491571917A5031990323 @default.
• W2491571917 hasAuthorship W2491571917A5053795585 @default.
• W2491571917 hasAuthorship W2491571917A5058855547 @default.
• W2491571917 hasAuthorship W2491571917A5077553920 @default.
• W2491571917 hasAuthorship W2491571917A5089876636 @default.
• W2491571917 hasAuthorship W2491571917A5090917103 @default.
• W2491571917 hasBestOaLocation W24915719171 @default.
• W2491571917 hasConcept C104317684 @default.
• W2491571917 hasConcept C134459356 @default.
• W2491571917 hasConcept C170493617 @default.
• W2491571917 hasConcept C173396325 @default.
• W2491571917 hasConcept C174510640 @default.

• next