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- W2491668144 abstract "Developmental changes in ion channels include alterations in the types, the number, and the kinetic properties. As a consequence of these changes resting potential (RP) and action potential (AP) are altered greatly during the developmental stages. This chapter focuses primarily on the ion channels of cardiomyocytes, where most is known about the developmental changes. The hyperpolarization of RP during development can be accounted for by the increase in I K(IR) and the resultant decrease in the P Na / P K ratio. This increase in I K(IR) results from changes in single channel conductance, and in the number and open probability of the channel. Muscarinic K + channel, a member of an inward rectifier K + channel family, is abundant in supraventricular tissues. This channel is characterized by the stimulation of acetylcholine and is often referred to as the Ach-activated K + channel. The fast Na + current increases markedly during development and it is responsible for the increase in the AP rate of rise. The fast Na + current in embryonic/fetal hearts has a significant sustained component, which decreases during development, contributing at least in part, to the abbreviation of AP duration." @default.
- W2491668144 created "2016-08-23" @default.
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- W2491668144 date "2001-01-01" @default.
- W2491668144 modified "2023-09-27" @default.
- W2491668144 title "Developmental Changes of Ion Channels" @default.
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- W2491668144 doi "https://doi.org/10.1016/b978-012656975-9/50043-2" @default.
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