Matches in SemOpenAlex for { <https://semopenalex.org/work/W2491805679> ?p ?o ?g. }
- W2491805679 endingPage "452" @default.
- W2491805679 startingPage "425" @default.
- W2491805679 abstract "Lipophilicity together with its descriptors and related plots is an area that has undergone enormous development since the first edition of Comprehensive Medicinal Chemistry. This increasing interest towards lipophilicity can be ascribed to its proven fundamental relevance in absorption, distribution, metabolism, excretion, and toxicity (ADMET) studies. As a consequence data on lipophilicity is currently being applied in three areas: (1) values to be used in quantitative structure−activity relationship (QSAR) studies (the earliest applications); (2) as molecular determinants to be applied to physicochemical screening in ADME-tox predictions (recent applications); and (3) as structural information about the biological behavior of drug candidates (very recent applications). In this chapter we first define lipophilicity descriptors and related plots used in medicinal chemistry. We then briefly survey those chemical forces encoded in lipophilicity to allow an understanding of the significance of the plethora of descriptors available today through low-throughput (LT) and high-throughput (HT) technologies. Finally, the lipophilicity of ionizable compounds in their neutral and ionized forms is extensively discussed, along with hydrophobic ion pairs (HIPs) and the classification of zwitterions." @default.
- W2491805679 created "2016-08-23" @default.
- W2491805679 creator A5040574865 @default.
- W2491805679 creator A5056407362 @default.
- W2491805679 creator A5063653917 @default.
- W2491805679 date "2007-01-01" @default.
- W2491805679 modified "2023-10-10" @default.
- W2491805679 title "Lipophilicity, Polarity, and Hydrophobicity" @default.
- W2491805679 cites W148815157 @default.
- W2491805679 cites W1493431793 @default.
- W2491805679 cites W1499541462 @default.
- W2491805679 cites W1519509748 @default.
- W2491805679 cites W1530136168 @default.
- W2491805679 cites W1534467616 @default.
- W2491805679 cites W1542214212 @default.
- W2491805679 cites W1568560565 @default.
- W2491805679 cites W1580991720 @default.
- W2491805679 cites W1592043509 @default.
- W2491805679 cites W1845084564 @default.
- W2491805679 cites W19456759 @default.
- W2491805679 cites W1964379108 @default.
- W2491805679 cites W1965107401 @default.
- W2491805679 cites W1971374309 @default.
- W2491805679 cites W1973410261 @default.
- W2491805679 cites W1977012788 @default.
- W2491805679 cites W1977455656 @default.
- W2491805679 cites W1977474883 @default.
- W2491805679 cites W1977570489 @default.
- W2491805679 cites W1980189764 @default.
- W2491805679 cites W1980293572 @default.
- W2491805679 cites W1983986879 @default.
- W2491805679 cites W1986878909 @default.
- W2491805679 cites W1989314543 @default.
- W2491805679 cites W1989925025 @default.
- W2491805679 cites W1993265362 @default.
- W2491805679 cites W1993278004 @default.
- W2491805679 cites W1994629475 @default.
- W2491805679 cites W1995495408 @default.
- W2491805679 cites W1997495339 @default.
- W2491805679 cites W1998700502 @default.
- W2491805679 cites W1999711931 @default.
- W2491805679 cites W2002030120 @default.
- W2491805679 cites W2002048138 @default.
- W2491805679 cites W2002864487 @default.
- W2491805679 cites W2003512894 @default.
- W2491805679 cites W2005940893 @default.
- W2491805679 cites W2009173404 @default.
- W2491805679 cites W2009270911 @default.
- W2491805679 cites W2009335994 @default.
- W2491805679 cites W2010321956 @default.
- W2491805679 cites W2012975843 @default.
- W2491805679 cites W2014368111 @default.
- W2491805679 cites W2017499341 @default.
- W2491805679 cites W2017843836 @default.
- W2491805679 cites W2022804932 @default.
- W2491805679 cites W2025467800 @default.
- W2491805679 cites W2026194834 @default.
- W2491805679 cites W2027232677 @default.
- W2491805679 cites W2027518385 @default.
- W2491805679 cites W2030823283 @default.
- W2491805679 cites W2031553055 @default.
- W2491805679 cites W2032353075 @default.
- W2491805679 cites W2032517731 @default.
- W2491805679 cites W2034407127 @default.
- W2491805679 cites W2035622829 @default.
- W2491805679 cites W2036882287 @default.
- W2491805679 cites W2039419728 @default.
- W2491805679 cites W2039590330 @default.
- W2491805679 cites W2043922290 @default.
- W2491805679 cites W2044454707 @default.
- W2491805679 cites W2045329641 @default.
- W2491805679 cites W2048689738 @default.
- W2491805679 cites W2049684731 @default.
- W2491805679 cites W2049784617 @default.
- W2491805679 cites W2054411380 @default.
- W2491805679 cites W2055726315 @default.
- W2491805679 cites W2057090099 @default.
- W2491805679 cites W2057155675 @default.
- W2491805679 cites W2057638688 @default.
- W2491805679 cites W2058540171 @default.
- W2491805679 cites W2058573317 @default.
- W2491805679 cites W2061452006 @default.
- W2491805679 cites W2062080743 @default.
- W2491805679 cites W2062854548 @default.
- W2491805679 cites W2064761203 @default.
- W2491805679 cites W2065122540 @default.
- W2491805679 cites W2065458102 @default.
- W2491805679 cites W2066609060 @default.
- W2491805679 cites W2070434500 @default.
- W2491805679 cites W2071879023 @default.
- W2491805679 cites W2072813311 @default.
- W2491805679 cites W2073101936 @default.
- W2491805679 cites W2074096820 @default.
- W2491805679 cites W2075328730 @default.
- W2491805679 cites W2080213998 @default.
- W2491805679 cites W2082214060 @default.
- W2491805679 cites W2086077780 @default.
- W2491805679 cites W2086448351 @default.