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- W2491866708 abstract "The tricyclic antidepressant drugs (TCA) are widely used in the treatment of depression. Since there are marked interindividual differences in the steady state concentrations of a TCA in plasma, the monitoring of the plasma concentrations as a guide to effective dosage has been developed. There are indications that both high and low concentrations of nortriptyline (NT), for example, are associated with poor clinical responses (Åsberg, 1974; Kragh-Sørensen et al., 1976), while the response may increase linearly with the plasma concentrations of imipramine and amitriptyline (AMI) (Gram, 1980).KeywordsHigh Pressure Liquid ChromatographicTertiary AmineSuccinic AnhydrideClinical Chemistry LaboratoryPoor Clinical ResponseThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
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- W2491866708 date "1981-01-01" @default.
- W2491866708 modified "2023-09-22" @default.
- W2491866708 title "Radioimmunoassay of tricyclic antidepressants" @default.
- W2491866708 doi "https://doi.org/10.1007/978-1-349-05929-4_3" @default.
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