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- W2491869867 endingPage "569" @default.
- W2491869867 startingPage "549" @default.
- W2491869867 abstract "Encapsulation can be divided into two major designs, viz. intravascular devices and extravascular devices. There are categories of geometry: tissue can be enveloped in macrocapsules and in microcapsules. The macrocapsules contain groups of cells enveloped together in one immunoisolating membrane that can be implanted as an extravascular and intravascular device. With microencapsulation, the groups of cells or tissues such as pancreatic islets are individually enveloped by their own capsule. This chapter discusses the biocompatibility issues in the application of polymers for cell encapsulation since optimal biocompatibility has been a major challenge in the application of cell encapsulation. The different types of molecules applied in encapsulation have been discussed. The concept of ‘smart' membranes in the field of extravascular macroencapsulation has brought new optimism into the field since the versatile properties of these membranes might facilitate the transport of nutrient and other essential molecules to the cells in the relatively large capsules without interfering with immunoprotective properties of macrocapsules. Although the number of scientific publications on these new materials are still limited, it is predictable that the current attention for nanotechnology would lead to more ‘smart' membranes and increased insight into the requirements these membranes have to meet in order to allow for adequate survival of the enveloped tissues. It is conceivable that it would lead to a renewed interest in macroencapsulation." @default.
- W2491869867 created "2016-08-23" @default.
- W2491869867 creator A5002327084 @default.
- W2491869867 date "2008-01-01" @default.
- W2491869867 modified "2023-09-23" @default.
- W2491869867 title "Natural-based polymers for encapsulation of living cells: Fundamentals, applications and challenges" @default.
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