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- W2491962436 abstract "Fifth AACR International Conference on Frontiers in Cancer Prevention Research, Nov 12-15, 2006B145 We examined the effect of supplementation with four different combinations of vitamins and minerals on the prevention of hepatocellular carcinoma (HCC) mortality among 29,450 healthy adults from a nutrient-inadequate population in Linxian, China. In accord with a partial factorial design, the participants were randomly assigned to take either a vitamin/mineral combination or a placebo daily for 5 ¼ years. The combinations tested in this trial were: factor A = retinol and zinc; factor B = riboflavin and niacin; factor C = ascorbic acid and molybdenum; factor D = beta-carotene, alpha-tocopherol, and selenium. All doses were 1-2 times US RDAs. HCC deaths (n = 151) identified during the trial period (1986 - 1991) and ten years after the trial ended (1991 - 2001) were the study outcome. No significant differences in HCC death rates were found for any of the four combinations of supplements tested in this study, using log-rank tests (all P-values >0.20), or Cox proportional hazards models adjusted for age, sex, commune, and other treatments. However, age and sex significantly modified the effects of the supplements. Factor A and factor B significantly reduced the risk of HCC death in individuals younger than 55 years of age at randomization (P = 0.049 and 0.025, respectively) but not in individuals ≥ 55 years of age (P = 0.79 and 0.57, respectively). Factor C marginally significantly reduced the risk of HCC death in males (P = 0.058) but not in females (P = 0.37). Supplementation with combinations of vitamins and minerals at nutrient-repletion levels for 5 ¼ years reduced HCC mortality in certain subgroups of this nutrient-inadequate population in Linxian, China." @default.
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- W2491962436 date "2006-12-01" @default.
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- W2491962436 title "Chemoprevention of hepatocellular carcinoma: A randomized, double-blind trial in Linxian, China." @default.
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