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- W2492020117 abstract "High-frequency deep brain stimulation (DBS) is a widely used therapy for advanced Parkinson’s disease (PD) management. However, the mechanisms by which DBS exerts its alleviating effect remain to be described. Furthermore, due to its non-adaptive nature, standard DBS is not ideally suited for the treatment of this highly dynamic and progressive disorder. We have devised several closed-loop stimulation strategies for PD and tested them in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) primate model of PD. These included stimulation of the internal pallidal segment (GPi) according to a predefined trigger in the ongoing neuronal activity. Application of pallido-pallidal closed-loop stimulation leads to dissociation between changes in basal ganglia (BG) discharge rates and patterns, providing insights into PD pathophysiology. Notably, cortico-pallidal closed-loop stimulation has a significantly greater effect on akinesia and on cortical and pallidal discharge patterns than standard open-loop DBS and matched control stimulation paradigms. These results demonstrate that closed-loop DBS paradigms, by modulating pathological oscillatory activity rather than the discharge rate of the BG-cortical networks, may afford more effective management of advanced PD. Such strategies have the potential to be effective in additional brain disorders in which a pathological neuronal discharge pattern can be recognized." @default.
- W2492020117 created "2016-08-23" @default.
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- W2492020117 date "2016-03-01" @default.
- W2492020117 modified "2023-09-27" @default.
- W2492020117 title "Closed-loop DBS in the non-human primate model of Parkinsonism" @default.
- W2492020117 doi "https://doi.org/10.1016/j.clinph.2015.11.127" @default.
- W2492020117 hasPublicationYear "2016" @default.
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