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- W2492080246 abstract "The primary response to a stressful event is activation of the hypothalamic–pituitary–adrenal axis. The stress response results in the synthesis and release of corticotropin-releasing hormone (CRH) from the hypothalamus, followed by an increased release of proopiomelanocortin peptides (adrenocorticotropic hormone, melanocyte-stimulating hormones, and endorphins) from the pituitary gland. Adrenocorticotropic hormone (ACTH) acts on the adrenal gland to cause release of glucocorticoids. The initial isolation of CRH, a 41-amino acid peptide, was based on its function as the major secretagogue of ACTH. Three more mammalian CRH-related ligands, urocortin (Ucn), urocortin II (Ucn 2), and urocortin III (Ucn 3), have now been cloned. The importance of the CRH system as a major integrator of behavioral, autonomic and endocrine responses to stress is underscored by its effects on learning and memory, Alzheimer's and Parkinson disease, appetite and weight control, addiction, cancer and a possible role in affective disorders such as melancholic depression. The diverse functions of the CRH peptides in physiology and disease is attributed to the downstream signaling pathways they modulate in a diverse number of cell types and tissues and disease states." @default.
- W2492080246 created "2016-08-23" @default.
- W2492080246 creator A5070212011 @default.
- W2492080246 date "2017-01-01" @default.
- W2492080246 modified "2023-09-25" @default.
- W2492080246 title "Corticotropin-Releasing Hormone Receptor Signaling ☆" @default.
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