FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2492182430> ?p ?o ?g. }

• W2492182430 endingPage "e1006184" @default.
• W2492182430 startingPage "e1006184" @default.
• W2492182430 abstract "Misfolded proteins challenge the ability of cells to maintain protein homeostasis and can accumulate into toxic protein aggregates. As a consequence, cells have adopted a number of protein quality control pathways to prevent protein aggregation, promote protein folding, and target terminally misfolded proteins for degradation. In this study, we employed a thermosensitive allele of the yeast Guk1 guanylate kinase as a model misfolded protein to investigate degradative protein quality control pathways. We performed a flow cytometry based screen to identify factors that promote proteasomal degradation of proteins misfolded as the result of missense mutations. In addition to the E3 ubiquitin ligase Ubr1, we identified the prefoldin chaperone subunit Gim3 as an important quality control factor. Whereas the absence of GIM3 did not impair proteasomal function or the ubiquitination of the model substrate, it led to the accumulation of the poorly soluble model substrate in cellular inclusions that was accompanied by delayed degradation. We found that Gim3 interacted with the Guk1 mutant allele and propose that prefoldin promotes the degradation of the unstable model substrate by maintaining the solubility of the misfolded protein. We also demonstrated that in addition to the Guk1 mutant, prefoldin can stabilize other misfolded cytosolic proteins containing missense mutations." @default.
• W2492182430 created "2016-08-23" @default.
• W2492182430 creator A5042454677 @default.
• W2492182430 creator A5046029600 @default.
• W2492182430 creator A5060916439 @default.
• W2492182430 creator A5075741260 @default.
• W2492182430 date "2016-07-22" @default.
• W2492182430 modified "2023-10-12" @default.
• W2492182430 title "Prefoldin Promotes Proteasomal Degradation of Cytosolic Proteins with Missense Mutations by Maintaining Substrate Solubility" @default.
• W2492182430 cites W1483766000 @default.
• W2492182430 cites W1501921984 @default.
• W2492182430 cites W1514121656 @default.
• W2492182430 cites W1528012035 @default.
• W2492182430 cites W1856284285 @default.
• W2492182430 cites W1887260230 @default.
• W2492182430 cites W1967025628 @default.
• W2492182430 cites W1968149522 @default.
• W2492182430 cites W1971108880 @default.
• W2492182430 cites W1973634405 @default.
• W2492182430 cites W1973765041 @default.
• W2492182430 cites W1974778184 @default.
• W2492182430 cites W1981067425 @default.
• W2492182430 cites W1988165326 @default.
• W2492182430 cites W1988624915 @default.
• W2492182430 cites W1993251792 @default.
• W2492182430 cites W2003873320 @default.
• W2492182430 cites W2008686051 @default.
• W2492182430 cites W2009086983 @default.
• W2492182430 cites W2011368229 @default.
• W2492182430 cites W2015040639 @default.
• W2492182430 cites W2017152530 @default.
• W2492182430 cites W2023490488 @default.
• W2492182430 cites W2024543003 @default.
• W2492182430 cites W2028380145 @default.
• W2492182430 cites W2030641676 @default.
• W2492182430 cites W2033624740 @default.
• W2492182430 cites W2034108516 @default.
• W2492182430 cites W2037786814 @default.
• W2492182430 cites W2043586610 @default.
• W2492182430 cites W2045791858 @default.
• W2492182430 cites W2045929752 @default.
• W2492182430 cites W2051123135 @default.
• W2492182430 cites W2058236814 @default.
• W2492182430 cites W2058775823 @default.
• W2492182430 cites W2062404215 @default.
• W2492182430 cites W2066672686 @default.
• W2492182430 cites W2074273512 @default.
• W2492182430 cites W2076159058 @default.
• W2492182430 cites W2077181854 @default.
• W2492182430 cites W2078721873 @default.
• W2492182430 cites W2092986760 @default.
• W2492182430 cites W2095999275 @default.
• W2492182430 cites W2103151604 @default.
• W2492182430 cites W2109350663 @default.
• W2492182430 cites W2110125737 @default.
• W2492182430 cites W2119097398 @default.
• W2492182430 cites W2123438831 @default.
• W2492182430 cites W2128679613 @default.
• W2492182430 cites W2129805026 @default.
• W2492182430 cites W2132296982 @default.
• W2492182430 cites W2136201006 @default.
• W2492182430 cites W2138309685 @default.
• W2492182430 cites W2143500687 @default.
• W2492182430 cites W2148505202 @default.
• W2492182430 cites W2150195578 @default.
• W2492182430 cites W2150775797 @default.
• W2492182430 cites W2152217159 @default.
• W2492182430 cites W2158884952 @default.
• W2492182430 cites W2177843732 @default.
• W2492182430 cites W2347555873 @default.
• W2492182430 cites W2350919937 @default.
• W2492182430 cites W3140521214 @default.
• W2492182430 doi "https://doi.org/10.1371/journal.pgen.1006184" @default.
• W2492182430 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4957761" @default.
• W2492182430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27448207" @default.
• W2492182430 hasPublicationYear "2016" @default.
• W2492182430 type Work @default.
• W2492182430 sameAs 2492182430 @default.
• W2492182430 citedByCount "37" @default.
• W2492182430 countsByYear W24921824302017 @default.
• W2492182430 countsByYear W24921824302018 @default.
• W2492182430 countsByYear W24921824302019 @default.
• W2492182430 countsByYear W24921824302020 @default.
• W2492182430 countsByYear W24921824302021 @default.
• W2492182430 countsByYear W24921824302022 @default.
• W2492182430 countsByYear W24921824302023 @default.
• W2492182430 crossrefType "journal-article" @default.
• W2492182430 hasAuthorship W2492182430A5042454677 @default.
• W2492182430 hasAuthorship W2492182430A5046029600 @default.
• W2492182430 hasAuthorship W2492182430A5060916439 @default.
• W2492182430 hasAuthorship W2492182430A5075741260 @default.
• W2492182430 hasBestOaLocation W24921824301 @default.
• W2492182430 hasConcept C104317684 @default.
• W2492182430 hasConcept C131312102 @default.
• W2492182430 hasConcept C134459356 @default.
• W2492182430 hasConcept C136238340 @default.
• W2492182430 hasConcept C143065580 @default.
• W2492182430 hasConcept C162863750 @default.

• next