FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W249237816> ?p ?o ?g. }

• W249237816 endingPage "5538" @default.
• W249237816 startingPage "5531" @default.
• W249237816 abstract "We have isolated an extragenic suppressor, FAM1-1, which is able to restore respiratory growth to a deletion of the CEM1 gene (mitochondrial beta-keto-acyl synthase). The sequence of the suppressor strongly suggests that it encodes a long-chain fatty acid CoA ligase (fatty-acyl-CoA synthetase). We have also cloned and sequenced the wild-type FAM1 gene, which is devoid of suppressor activity. The comparison of the two sequences shows that the suppressor mutation is an A-->T transversion, which creates a new initiation codon and adds 18 amino acids to the N-terminus of the protein. This extension has all the characteristics of a mitochondrial targeting sequence, whilst the N-terminus of the wild-type protein has none of these characteristics. In vitro mitochondrial import experiments show that the N-terminal half of the suppressor protein, but not of the wild-type, is transported into mitochondria. Thus, we hypothesize that the suppressor acts by changing the subcellular localization of the protein and relocating at least some of the enzyme from the cytosol to the mitochondria. These results support the hypothesis that some form of fatty acid synthesis, specific for the mitochondria, is essential for the function of the organelle." @default.
• W249237816 created "2016-06-24" @default.
• W249237816 creator A5044175843 @default.
• W249237816 creator A5075640166 @default.
• W249237816 creator A5078924227 @default.
• W249237816 creator A5091227473 @default.
• W249237816 date "1994-12-01" @default.
• W249237816 modified "2023-09-26" @default.
• W249237816 title "Subcellular relocalization of a long-chain fatty acid CoA ligase by a suppressor mutation alleviates a respiration deficiency in Saccharomyces cerevisiae." @default.
• W249237816 cites W1547269929 @default.
• W249237816 cites W1603411458 @default.
• W249237816 cites W1727372 @default.
• W249237816 cites W1921046052 @default.
• W249237816 cites W1968293448 @default.
• W249237816 cites W1969737313 @default.
• W249237816 cites W1976210582 @default.
• W249237816 cites W1981261838 @default.
• W249237816 cites W2002173318 @default.
• W249237816 cites W2015292449 @default.
• W249237816 cites W2028153237 @default.
• W249237816 cites W2028287211 @default.
• W249237816 cites W2029195137 @default.
• W249237816 cites W2042329322 @default.
• W249237816 cites W2044131412 @default.
• W249237816 cites W2048222754 @default.
• W249237816 cites W2052656114 @default.
• W249237816 cites W2055043387 @default.
• W249237816 cites W2065396611 @default.
• W249237816 cites W2065484340 @default.
• W249237816 cites W2067220884 @default.
• W249237816 cites W2068602303 @default.
• W249237816 cites W2084737875 @default.
• W249237816 cites W2089087969 @default.
• W249237816 cites W2094031081 @default.
• W249237816 cites W2126947658 @default.
• W249237816 cites W2143486069 @default.
• W249237816 cites W2151368608 @default.
• W249237816 cites W2152845055 @default.
• W249237816 cites W2162692258 @default.
• W249237816 cites W2418586621 @default.
• W249237816 cites W2885461657 @default.
• W249237816 cites W41914561 @default.
• W249237816 doi "https://doi.org/10.1002/j.1460-2075.1994.tb06890.x" @default.
• W249237816 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/395515" @default.
• W249237816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7988550" @default.
• W249237816 hasPublicationYear "1994" @default.
• W249237816 type Work @default.
• W249237816 sameAs 249237816 @default.
• W249237816 citedByCount "43" @default.
• W249237816 countsByYear W2492378162012 @default.
• W249237816 countsByYear W2492378162013 @default.
• W249237816 countsByYear W2492378162015 @default.
• W249237816 countsByYear W2492378162017 @default.
• W249237816 countsByYear W2492378162018 @default.
• W249237816 countsByYear W2492378162020 @default.
• W249237816 countsByYear W2492378162021 @default.
• W249237816 crossrefType "journal-article" @default.
• W249237816 hasAuthorship W249237816A5044175843 @default.
• W249237816 hasAuthorship W249237816A5075640166 @default.
• W249237816 hasAuthorship W249237816A5078924227 @default.
• W249237816 hasAuthorship W249237816A5091227473 @default.
• W249237816 hasBestOaLocation W2492378161 @default.
• W249237816 hasConcept C104317684 @default.
• W249237816 hasConcept C153911025 @default.
• W249237816 hasConcept C167625842 @default.
• W249237816 hasConcept C175114707 @default.
• W249237816 hasConcept C181199279 @default.
• W249237816 hasConcept C207230331 @default.
• W249237816 hasConcept C26567756 @default.
• W249237816 hasConcept C2777576037 @default.
• W249237816 hasConcept C28859421 @default.
• W249237816 hasConcept C501734568 @default.
• W249237816 hasConcept C55493867 @default.
• W249237816 hasConcept C64872895 @default.
• W249237816 hasConcept C83713313 @default.
• W249237816 hasConcept C86803240 @default.
• W249237816 hasConcept C98539663 @default.
• W249237816 hasConceptScore W249237816C104317684 @default.
• W249237816 hasConceptScore W249237816C153911025 @default.
• W249237816 hasConceptScore W249237816C167625842 @default.
• W249237816 hasConceptScore W249237816C175114707 @default.
• W249237816 hasConceptScore W249237816C181199279 @default.
• W249237816 hasConceptScore W249237816C207230331 @default.
• W249237816 hasConceptScore W249237816C26567756 @default.
• W249237816 hasConceptScore W249237816C2777576037 @default.
• W249237816 hasConceptScore W249237816C28859421 @default.
• W249237816 hasConceptScore W249237816C501734568 @default.
• W249237816 hasConceptScore W249237816C55493867 @default.
• W249237816 hasConceptScore W249237816C64872895 @default.
• W249237816 hasConceptScore W249237816C83713313 @default.
• W249237816 hasConceptScore W249237816C86803240 @default.
• W249237816 hasConceptScore W249237816C98539663 @default.
• W249237816 hasIssue "23" @default.
• W249237816 hasLocation W2492378161 @default.
• W249237816 hasLocation W2492378162 @default.
• W249237816 hasLocation W2492378163 @default.
• W249237816 hasOpenAccess W249237816 @default.
• W249237816 hasPrimaryLocation W2492378161 @default.

• next