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• W2492437103 abstract "It is well known that DNA replication affects the stability of several trinucleotide repeats, but whether replication profiles of human loci carrying an expanded repeat differ from those of normal alleles is poorly understood in the endogenous context. We investigated this issue using cell lines from Friedreich's ataxia patients, homozygous for a GAA-repeat expansion in intron 1 of the Frataxin gene. By interphase, FISH we found that in comparison to the normal Frataxin sequence the replication of expanded alleles is slowed or delayed. According to molecular combing, origins never fired within the normal Frataxin allele. In contrast, in mutant alleles dormant origins are recruited within the gene, causing a switch of the prevalent fork direction through the expanded repeat. Furthermore, a global modification of the replication profile, involving origin choice and a differential distribution of unidirectional forks, was observed in the surrounding 850 kb region. These data provide a wide-view of the interplay of events occurring during replication of genes carrying an expanded repeat." @default.
• W2492437103 created "2016-08-23" @default.
• W2492437103 creator A5050558713 @default.
• W2492437103 creator A5082850565 @default.
• W2492437103 creator A5090776655 @default.
• W2492437103 date "2016-07-22" @default.
• W2492437103 modified "2023-09-23" @default.
• W2492437103 title "The Replication of Frataxin Gene Is Assured by Activation of Dormant Origins in the Presence of a GAA-Repeat Expansion" @default.
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• W2492437103 doi "https://doi.org/10.1371/journal.pgen.1006201" @default.
• W2492437103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4957762" @default.
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• W2492437103 hasPublicationYear "2016" @default.
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