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• W2492453288 abstract "Abstract Ketamine is a relatively safe dissociative anesthetic that works through antagonism at the N-methyl- d -aspartate receptor. At subanesthetic doses, it produces an array of transient alterations in consciousness. These psychoactive effects, also designated “emergent phenomena” when associated with emergence from anesthesia, have historically been considered bothersome and possibly dangerous. Furthermore, they largely account for the abuse liability of ketamine. Recent psychiatric research with and clinical applications of subanesthetic ketamine infusions have led to reconsideration of these psychoactive effects, with some research indicating that they may be implicated in the therapeutic mechanisms of ketamine. Other research suggests that these effects are extraneous epiphenomena that confer more risk than they do benefit. It remains to be determined whether agents that work through neurobiological pathways similar to those of ketamine, but that have been selected so as not to engender psychoactive effects, will be associated with the same benefits. As the field addresses these questions, it remains important to restrict the use of ketamine to highly specialized and research settings, where controlled administration with safeguards in place can effectively mitigate its risks." @default.
• W2492453288 created "2016-08-23" @default.
• W2492453288 creator A5077268846 @default.
• W2492453288 creator A5080442651 @default.
• W2492453288 date "2016-01-01" @default.
• W2492453288 modified "2023-09-23" @default.
• W2492453288 title "Ketamine Usage at Subanesthetic Doses and Psychoactive Effects" @default.
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• W2492453288 doi "https://doi.org/10.1016/b978-0-12-800212-4.00063-7" @default.
• W2492453288 hasPublicationYear "2016" @default.
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