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- W2492498975 abstract "Process chromatography will continue to play a key role in industrial scale operations involving commercialization of recombinant DNA products. The strategy used in design of a commercial-scale process is dependent on whether the product is a well defined chemical entity, or represents a family of products. For example, human insulin processing involves high resolution techniques because anayltical tools can be used to define insulin as a unique chemical entity. However, protein products with considerable post-translational modifications, especially glycoproteins, are heterogeneous mixtures, just like their naturally occurring counterparts. Processing of these proteins is most efficient when group specific techniques, such as affinity methods, are used. In addition, arguments are given for why process optimization work, especially for a mature process, should focus on the latter steps of the process." @default.
- W2492498975 created "2016-08-23" @default.
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- W2492498975 date "1993-05-24" @default.
- W2492498975 modified "2023-09-27" @default.
- W2492498975 title "Process Chromatography in Production of Recombinant Products" @default.
- W2492498975 doi "https://doi.org/10.1021/bk-1993-0529.ch004" @default.
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