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- W2492612892 abstract "Highly active antiretroviral therapy (HAART) has proven effective in reducing systemic viral loads in HIV patients but has been unable to completely eliminate the HIV from quiescent viral sequestered sites such as the brain, thus contributing to a spectrum of HIV-associated neurological disorders (HAND) defined as neuro-AIDS. Technological advances in nanoparticle design have increased their applicability in biomedical applications and show great promise for HIV therapeutics. The blood–brain barrier (BBB) is a limiting factor for the delivery of therapeutic agents into the central nervous system (CNS). BBB breakdown plays an important role in the pathogenesis of HAND. The tight junctions play a key role in the regulation of the structural and functional integrity of the BBB. No information is available on TJ modulation by nanoparticles commonly used in HIV-1 nanotherapeutics. This chapter highlights the effect of nanoparticles on BBB modulation and its implication for CNS nanotherapeutics." @default.
- W2492612892 created "2016-08-23" @default.
- W2492612892 creator A5038905034 @default.
- W2492612892 creator A5045801673 @default.
- W2492612892 creator A5052017501 @default.
- W2492612892 creator A5061065579 @default.
- W2492612892 creator A5067232021 @default.
- W2492612892 creator A5072121658 @default.
- W2492612892 creator A5072872357 @default.
- W2492612892 creator A5088792183 @default.
- W2492612892 date "2015-01-01" @default.
- W2492612892 modified "2023-09-24" @default.
- W2492612892 title "Nanotherapeutic Approach to Targeting HIV-1 in the CNS" @default.
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