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• W2492775364 endingPage "e0159707" @default.
• W2492775364 startingPage "e0159707" @default.
• W2492775364 abstract "Weaning of dairy calves is an early life husbandry management practice which involves the changeover from a liquid to a solid feed based diet. The objectives of the study were to use RNA-seq technology to examine the effect of (i) breed and (ii) gradual weaning, on the whole blood mRNA transcriptome of artificially reared Holstein-Friesian and Jersey calves. The calves were gradually weaned over 14 days (day (d) -13 to d 0) and mRNA transcription was examined one day before gradual weaning was initiated (d -14), one day after weaning (d 1), and 8 days after weaning (d 8). On d -14, 550 genes were differentially expressed between Holstein-Friesian and Jersey calves, while there were 490 differentially expressed genes (DEG) identified on d 1, and 411 DEG detected eight days after weaning (P < 0.05; FDR < 0.1). No genes were differentially expressed within breed, in response to gradual weaning (P > 0.05). The pathways, gene ontology terms, and biological functions consistently over-represented among the DEG between Holstein-Friesian and Jersey were associated with the immune response and immune cell signalling, specifically chemotaxis. Decreased transcription of several cytokines, chemokines, immunoglobulin-like genes, phagocytosis-promoting receptors and g-protein coupled receptors suggests decreased monocyte, natural killer cell, and T lymphocyte, chemotaxis and activation in Jersey compared to Holstein-Friesian calves. Knowledge of breed-specific immune responses could facilitate health management practices better tailored towards specific disease sensitivities of Holstein-Friesian and Jersey calves. Gradual weaning did not compromise the welfare of artificially-reared dairy calves, evidenced by the lack of alterations in the expression of any genes in response to gradual weaning." @default.
• W2492775364 created "2016-08-23" @default.
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• W2492775364 date "2016-08-01" @default.
• W2492775364 modified "2023-10-15" @default.
• W2492775364 title "Characterisation of the Whole Blood mRNA Transcriptome in Holstein-Friesian and Jersey Calves in Response to Gradual Weaning" @default.
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• W2492775364 doi "https://doi.org/10.1371/journal.pone.0159707" @default.
• W2492775364 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4968839" @default.
• W2492775364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27479136" @default.
• W2492775364 hasPublicationYear "2016" @default.
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