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- W2492783198 abstract "Keppra (Levetiracetam, LEV) represents a new class of antiepileptic drugs (AED) that modulates seizure-activity in epilepsy. Serving as an option for brain tumor patients suffering from seizures, LEV can be used to treat symptoms in patients with brain tumors and increase the sensitivity of Glioblastoma tumors to the chemotherapy drug, Temozolomide (TMZ). Aggressive treatments of TMZ chemotherapy present benefits toward butterfly glioblastoma (bGBM) patients. Patients diagnosed with bGBM, contain a high grade astrocytoma that crosses the midline via the corpus callosum and is considered to have a dismal prognosis that leads to no attempt of a curative resection. We predict that if LEV has the ability to sensitize glioblastoma behavior toward TMZ chemotherapy treatment, then LEV can serve as a chemotherapeutic agent in order to reach a differential diagnosis to cure bGBM patients. In this review, we discussed whether LEV can be used as a therapeutic agent for patients with bGBM, if so what are the pros and cons of this specific gene therapy and are we able to assess if there is a cross relationship between TMZ and LEV, which in turn provides potential benefits. Overall, it is evident that in connection to TMZ, LEV increases TMZ induced cytotoxicity in patients with bGBM, thus causing a sensitizing effect that provides advantageous and disadvantageous options for LEV as a therapeutic agent in bGBM patients." @default.
- W2492783198 created "2016-08-23" @default.
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- W2492783198 date "2016-05-12" @default.
- W2492783198 modified "2023-09-27" @default.
- W2492783198 title "Can the Pharmaceutical Drug Keppra (Levetiracetam) Be Used as a Therapeutic Agent for Patients with Butterfly Glioblastoma?" @default.
- W2492783198 doi "https://doi.org/10.15406/mojap.2016.02.00051" @default.
- W2492783198 hasPublicationYear "2016" @default.
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