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• W2492973443 abstract "The idiom “the straw that breaks the camel’s back” describes scenarios where seemingly minor incidents eventuate in a sudden, unexpected, and often detrimental downfall. In the case of atherosclerosis, over time multiple subclinical cellular events result in the development of unstable, vulnerable atherosclerotic lesions, which leads to the rupture of atherosclerotic plaques, culminating in the often catastrophic clinical manifestation of myocardial infarction or ischemic stroke. In this review, we first summarize lessons learned from autopsy studies, clinical investigations, and animal models mainly published in ATVB . We then present recent experimental studies published in ATVB that shed light on the underlying pathophysiological development of plaque instability and disruption, and how differential and sometimes maladaptive responses at cellular levels contribute to this complex process. These many publications in ATVB are a testament to the journal’s leading role in research on atherosclerotic plaque instability, an area of research with utmost translational relevance.Our understanding of the pathology of unstable, vulnerable atherosclerotic plaques is mainly based on a limited number of postmortem examinations of human coronary arteries and the analysis of resected surgical specimens from patients who underwent carotid endarterectomy and performed for primary/secondary prevention of transient ischemia attack or stroke.1–3 The histopathologic definition of unstable plaques includes, as the most central features, thin fibrous caps (thickness 40% of the total lesion volume).4–7 Importantly, repeated subclinical plaque ruptures, histologically and potentially macroscopically visible as intraplaque hemorrhage, are described as an additional cause of plaque instability.8 From an autopsy series of 800 cases of sudden coronary …" @default.
• W2492973443 created "2016-08-23" @default.
• W2492973443 creator A5010702763 @default.
• W2492973443 creator A5049936296 @default.
• W2492973443 creator A5067667648 @default.
• W2492973443 creator A5070752593 @default.
• W2492973443 creator A5085641688 @default.
• W2492973443 date "2016-08-01" @default.
• W2492973443 modified "2023-10-18" @default.
• W2492973443 title "Atherosclerotic Plaque Rupture" @default.
• W2492973443 cites W115717089 @default.
• W2492973443 cites W150221401 @default.
• W2492973443 cites W1793308124 @default.
• W2492973443 cites W1910666696 @default.
• W2492973443 cites W1927981016 @default.
• W2492973443 cites W1961416823 @default.
• W2492973443 cites W1967885627 @default.
• W2492973443 cites W196835504 @default.
• W2492973443 cites W1978081390 @default.
• W2492973443 cites W1980290838 @default.
• W2492973443 cites W1982033642 @default.
• W2492973443 cites W1986194263 @default.
• W2492973443 cites W1986341475 @default.
• W2492973443 cites W1997208476 @default.
• W2492973443 cites W1997518299 @default.
• W2492973443 cites W1997722136 @default.
• W2492973443 cites W2003018647 @default.
• W2492973443 cites W2006116816 @default.
• W2492973443 cites W2006124884 @default.
• W2492973443 cites W2011232682 @default.
• W2492973443 cites W2011424926 @default.
• W2492973443 cites W2017971249 @default.
• W2492973443 cites W2026281835 @default.
• W2492973443 cites W2027685709 @default.
• W2492973443 cites W2031047943 @default.
• W2492973443 cites W2036799308 @default.
• W2492973443 cites W2037045415 @default.
• W2492973443 cites W2041240891 @default.
• W2492973443 cites W2048332099 @default.
• W2492973443 cites W2050974836 @default.
• W2492973443 cites W2054203840 @default.
• W2492973443 cites W2057083638 @default.
• W2492973443 cites W2063704757 @default.
• W2492973443 cites W2069888156 @default.
• W2492973443 cites W2072190804 @default.
• W2492973443 cites W2074249358 @default.
• W2492973443 cites W2077792952 @default.
• W2492973443 cites W2083507739 @default.
• W2492973443 cites W2083795939 @default.
• W2492973443 cites W2092799386 @default.
• W2492973443 cites W2095819288 @default.
• W2492973443 cites W2097706205 @default.
• W2492973443 cites W2098596880 @default.
• W2492973443 cites W2099219058 @default.
• W2492973443 cites W2099892923 @default.
• W2492973443 cites W2100272414 @default.
• W2492973443 cites W2101415872 @default.
• W2492973443 cites W2101816788 @default.
• W2492973443 cites W2103088789 @default.
• W2492973443 cites W2103105662 @default.
• W2492973443 cites W2103365363 @default.
• W2492973443 cites W2103807508 @default.
• W2492973443 cites W2105865311 @default.
• W2492973443 cites W2106319388 @default.
• W2492973443 cites W2112360098 @default.
• W2492973443 cites W2113385672 @default.
• W2492973443 cites W2115593266 @default.
• W2492973443 cites W2119352838 @default.
• W2492973443 cites W2120439472 @default.
• W2492973443 cites W2124008781 @default.
• W2492973443 cites W2124989653 @default.
• W2492973443 cites W2125638994 @default.
• W2492973443 cites W2127062586 @default.
• W2492973443 cites W2130383679 @default.
• W2492973443 cites W2130794549 @default.
• W2492973443 cites W2131110587 @default.
• W2492973443 cites W2131471617 @default.
• W2492973443 cites W2131604815 @default.
• W2492973443 cites W2133858220 @default.
• W2492973443 cites W2133866061 @default.
• W2492973443 cites W2135588352 @default.
• W2492973443 cites W2137617248 @default.
• W2492973443 cites W2141024671 @default.
• W2492973443 cites W2142441861 @default.
• W2492973443 cites W2145304657 @default.
• W2492973443 cites W2146706268 @default.
• W2492973443 cites W2150795824 @default.
• W2492973443 cites W2151247869 @default.
• W2492973443 cites W2152054355 @default.
• W2492973443 cites W2153575245 @default.
• W2492973443 cites W2154073422 @default.
• W2492973443 cites W2156593520 @default.
• W2492973443 cites W2159511210 @default.
• W2492973443 cites W2160621473 @default.
• W2492973443 cites W2160909868 @default.
• W2492973443 cites W2161682643 @default.
• W2492973443 cites W2162121590 @default.
• W2492973443 cites W2162405407 @default.
• W2492973443 cites W2162794368 @default.
• W2492973443 cites W2162919004 @default.

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