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- W2492988362 abstract "Abstract Against the backdrop of the launch of the Human Genome Project, scientists from a variety of industries, academia and governmental organizations convened in late 1998 under the sponsorship of the International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) to deliberate on how best to advance the promising field of toxicogenomics. The landmark undertaking to sequence the human genome was enabled by the emergence of a variety of approaches and platforms for measuring changes in the expressions of thousands of genes simultaneously, and there was widespread interest in the toxicology community in applying this knowledge and the emerging technologies to safety assessment. This chapter describes the role played by the Health and Environmental Sciences Institute (HESI) Committee on the Application of Genomics to Mechanism-based Risk Assessment (HESI Genomics Committee) in facilitating a cross-industry, government and academic effort to explore the utility of genomics methods and technologies for improving the understanding of mechanisms of toxicity and advancing risk assessment, and its contributions to the development of multi-site biomarker validation approaches." @default.
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- W2492988362 date "2013-01-01" @default.
- W2492988362 modified "2023-09-27" @default.
- W2492988362 title "Biomarker Qualification – Past, Present and Future" @default.
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- W2492988362 doi "https://doi.org/10.1016/b978-0-12-391496-5.00012-0" @default.
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