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- W2493026441 abstract "Dr Farber’s success in achieving temporary remissions in children with acute lymphocytic leukaemia (Farber et al., 1948) stimulated the development of a number of new antileukaemic drugs which were capable of prolonging initial remissions. Although these early achievements made it clear that bone marrow leukaemia could be controlled by chemotherapy, meningeal infiltration proved much more resistant; the inability to prevent relapses in the central nervous system (CNS) called attention to meningeal leukaemia as a unique therapeutic problem. Inadequate drug concentrations in the cerebrospinal fluid appeared to be the principal reason for the ineffectiveness of chemotherapy; however, intrathecal administration of drugs resulted in only temporary control of the complication in most patients. Early attempts to treat CNS leukaemia with radiation of 1500 rads or less met with equally unsatisfactory results. It was clear from these experiences that meningeal involvement in acute lymphoblastic leukaemia (ALL) would pose one of the principal obstacles to cure of the disease." @default.
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- W2493026441 date "1979-01-01" @default.
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- W2493026441 title "Histopathogenesis of Meningeal Leukaemia and Complications of Therapy" @default.
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- W2493026441 doi "https://doi.org/10.1007/978-1-349-04285-2_1" @default.
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