FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2493131459> ?p ?o ?g. }

• W2493131459 abstract "Abstract Salmonella have many desirable properties as antitumour-agent due to its ability to proliferate inside tumours and induce tumour regression. Additionally, this bacterium can be genetically engineered to deliver therapeutic proteins intratumourally. The main limitation of this approach is the efficient release of therapeutic molecules from intratumoural bacteria. Here we have developed an inducible autolysis system based in the lysis operon of the lambda phage that, in response to anhydrotetracycline, lysates Salmonella thus releasing its content. The system was combined with a salicylate cascade system that allows efficient production of therapeutic molecules in response to aspirin and with a sifA mutation that liberates bacteria from the vacuoles to a cytosolic location. The combination of these three elements makes this strain a putative powerful instrument in cancer treatment. We have used this engineered strain for the intracellular production and delivery of Cp53 peptide. The engineered strain is able to sequentially produce and release the cytotoxic peptide while proliferating inside tumour cells, thus inducing host cell death. Our results show that temporal separation of protein production from protein release is essential to efficiently kill tumour cells. The combined system is a further step in the engineering of more efficient bacteria for cancer therapy." @default.
• W2493131459 created "2016-08-23" @default.
• W2493131459 creator A5002712715 @default.
• W2493131459 creator A5042377498 @default.
• W2493131459 creator A5055325773 @default.
• W2493131459 creator A5061091685 @default.
• W2493131459 creator A5077314074 @default.
• W2493131459 date "2016-07-28" @default.
• W2493131459 modified "2023-10-13" @default.
• W2493131459 title "Engineering Salmonella as intracellular factory for effective killing of tumour cells" @default.
• W2493131459 cites W1545921898 @default.
• W2493131459 cites W1585987688 @default.
• W2493131459 cites W1852844868 @default.
• W2493131459 cites W1896572732 @default.
• W2493131459 cites W1931581539 @default.
• W2493131459 cites W1968426638 @default.
• W2493131459 cites W1974016379 @default.
• W2493131459 cites W1979129905 @default.
• W2493131459 cites W1979507175 @default.
• W2493131459 cites W1983352357 @default.
• W2493131459 cites W1988411542 @default.
• W2493131459 cites W1995068068 @default.
• W2493131459 cites W1996239683 @default.
• W2493131459 cites W2002292653 @default.
• W2493131459 cites W2003190262 @default.
• W2493131459 cites W2008028087 @default.
• W2493131459 cites W2010108184 @default.
• W2493131459 cites W2012873467 @default.
• W2493131459 cites W2013563062 @default.
• W2493131459 cites W2015257503 @default.
• W2493131459 cites W2023429099 @default.
• W2493131459 cites W2025745970 @default.
• W2493131459 cites W2028222979 @default.
• W2493131459 cites W2045609136 @default.
• W2493131459 cites W2050540135 @default.
• W2493131459 cites W2059801013 @default.
• W2493131459 cites W2060079355 @default.
• W2493131459 cites W2063576137 @default.
• W2493131459 cites W2070461265 @default.
• W2493131459 cites W2073015589 @default.
• W2493131459 cites W2073909376 @default.
• W2493131459 cites W2086706870 @default.
• W2493131459 cites W2088172410 @default.
• W2493131459 cites W2093070945 @default.
• W2493131459 cites W2093410766 @default.
• W2493131459 cites W2098554880 @default.
• W2493131459 cites W2099472238 @default.
• W2493131459 cites W2110146529 @default.
• W2493131459 cites W2115734610 @default.
• W2493131459 cites W2116137883 @default.
• W2493131459 cites W2124096904 @default.
• W2493131459 cites W2129204554 @default.
• W2493131459 cites W2134618778 @default.
• W2493131459 cites W2139709150 @default.
• W2493131459 cites W2139971026 @default.
• W2493131459 cites W2143036860 @default.
• W2493131459 cites W2152369326 @default.
• W2493131459 cites W2152795516 @default.
• W2493131459 cites W2168280187 @default.
• W2493131459 cites W2168843400 @default.
• W2493131459 cites W2246941421 @default.
• W2493131459 cites W2260409955 @default.
• W2493131459 cites W2320950410 @default.
• W2493131459 cites W2394850841 @default.
• W2493131459 cites W2404160431 @default.
• W2493131459 cites W2417370606 @default.
• W2493131459 cites W4251431706 @default.
• W2493131459 cites W634014629 @default.
• W2493131459 doi "https://doi.org/10.1038/srep30591" @default.
• W2493131459 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4964584" @default.
• W2493131459 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27464652" @default.
• W2493131459 hasPublicationYear "2016" @default.
• W2493131459 type Work @default.
• W2493131459 sameAs 2493131459 @default.
• W2493131459 citedByCount "44" @default.
• W2493131459 countsByYear W24931314592017 @default.
• W2493131459 countsByYear W24931314592018 @default.
• W2493131459 countsByYear W24931314592019 @default.
• W2493131459 countsByYear W24931314592020 @default.
• W2493131459 countsByYear W24931314592021 @default.
• W2493131459 countsByYear W24931314592022 @default.
• W2493131459 countsByYear W24931314592023 @default.
• W2493131459 crossrefType "journal-article" @default.
• W2493131459 hasAuthorship W2493131459A5002712715 @default.
• W2493131459 hasAuthorship W2493131459A5042377498 @default.
• W2493131459 hasAuthorship W2493131459A5055325773 @default.
• W2493131459 hasAuthorship W2493131459A5061091685 @default.
• W2493131459 hasAuthorship W2493131459A5077314074 @default.
• W2493131459 hasBestOaLocation W24931314591 @default.
• W2493131459 hasConcept C104810894 @default.
• W2493131459 hasConcept C121608353 @default.
• W2493131459 hasConcept C153726182 @default.
• W2493131459 hasConcept C154317977 @default.
• W2493131459 hasConcept C181199279 @default.
• W2493131459 hasConcept C185592680 @default.
• W2493131459 hasConcept C202751555 @default.
• W2493131459 hasConcept C2781065037 @default.
• W2493131459 hasConcept C523546767 @default.
• W2493131459 hasConcept C54355233 @default.
• W2493131459 hasConcept C55493867 @default.

• next