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- W2493201720 abstract "Abstract People with mood disorders experience pathologic periods of either elevated (manic) or depressed mood. A roadblock to pathophysiologic understanding and therapeutic development for mood disorders is the poor understanding of genetic and molecular mechanisms contributing to these diseases. Mammalian target of rapamycin (mTOR) is an emerging pathway of interest in the field. Ketamine is one of the most promising fast-acting antidepressants under investigation for depression mood disorders and exerts its therapeutic effect through the mTOR pathway. This finding led to the hypothesis that mTOR may be an underlying pathophysiologic pathway in depression disorders. Meanwhile, in bipolar disorder, a mood disorder featuring both manic and depressed mood states, there is limited data regarding the role of mTOR." @default.
- W2493201720 created "2016-08-23" @default.
- W2493201720 creator A5004754441 @default.
- W2493201720 creator A5009501105 @default.
- W2493201720 creator A5032707511 @default.
- W2493201720 creator A5076334811 @default.
- W2493201720 date "2016-01-01" @default.
- W2493201720 modified "2023-10-18" @default.
- W2493201720 title "The Role of mTOR in Mood Disorders Pathophysiology and Treatment" @default.
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