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• W2493249533 endingPage "60735" @default.
• W2493249533 startingPage "60723" @default.
• W2493249533 abstract "While novel therapeutic approaches have profoundly improved survival of multiple myeloma (MM) patients, drug resistance and treatment refractoriness still persists. This obstacle highly demands thorough investigation into the root and underlying molecular mechanisms to develop more effective strategies. The advent of micro-RNAs (miRNAs) in the study of cancer biology and pathogenesis in recent years has revolutionized therapy in this field and particularly opened new windows to further understanding of tumor drug resistance. However; in spite of the fact that miRNAs involvement in MM pathogenesis and progression has been substantially evidenced, miRNA investigation in MM drug resistance is still in its infancy. Our knowledge of the potential role of miRNAs in MM drug resistance comes from few recent reports confirming that some miRNAs including miR-137/197, miR-21 and miR-221/222 could negatively modulate drug sensitivity of MM cells. Further continuous researches are required to exploit miRNAs to elucidate the critical mechanisms controlling drug resistance in MM. In this review, we will highlight the most recent observations on the role of miRNAs in MM drug resistance. Moreover, approaches and insights into clinical application of miRNAs to overcome MM drug resistance will be discussed." @default.
• W2493249533 created "2016-08-23" @default.
• W2493249533 creator A5018664175 @default.
• W2493249533 creator A5030583882 @default.
• W2493249533 creator A5072624948 @default.
• W2493249533 date "2016-08-02" @default.
• W2493249533 modified "2023-10-14" @default.
• W2493249533 title "Role of micro-RNAs in drug resistance of multiple myeloma" @default.
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