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- W2493278730 abstract "A highly diastereoselective Michael addition of (R)-N-tert-butanesulfinyl imidates 8 to α,β-unsaturated pyrazolidinone 3a has been developed to afford pyrazolidinones 10 possessing three contiguous stereocenters with good to excellent yield and excellent diastereoselectivity. A two-step conversion of reduction and cyclization provides the bicyclic pyrazolopiperidine 12 in a good yield. A series of pyrazolopiperidine derivatives 18 with a quaternary carbon center at C-3a are stereoselectively synthesized via alkylation or Michael addition." @default.
- W2493278730 created "2016-08-23" @default.
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- W2493278730 date "2016-08-03" @default.
- W2493278730 modified "2023-10-16" @default.
- W2493278730 title "Asymmetric Michael Addition Induced by (<i>R</i>)-<i>tert</i>-Butanesulfinamide and Syntheses of Chiral Pyrazolidinone Derivatives" @default.
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- W2493278730 doi "https://doi.org/10.1021/acs.joc.6b01237" @default.
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