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• W2493444967 abstract "BackgroundInhaled drugs are the mainstay of treatment for lung diseases such as asthma and chronic obstructive pulmonary disease. However, failure to use inhalation devices correctly can lead to a poorly controlled status. A vast number of inhalation devices exist and each device has specific requirements to achieve optimum inhalation of the drug. Currently, there is no overview of inhalation requirements considering all devices. This article presents a review of the literature on different inhalation device requirements and incorporates the data into a new inhalation flow algorithm.MethodsData from literature on commercially available inhalation devices were evaluated and parameters, such as inhalation flow rate, flow acceleration, inhalation volume, and inspiration time assessed for the required inhalation maneuver specific to the device. All agreed upon data points were used to develop an inhalation flow algorithm.ResultsThe literature analysis revealed availability of robust data for the required inhalation flow characteristics for most devices and thus for the development of an algorithm. For those devices for which these parameters are not published, the minimum required flow criteria were defined based on published data regarding individual aspects of aerosol quality.ConclusionsThis review provides an overview of inhalation devices available on the market regarding requirements for an acceptable inhalation maneuver and shows which goals should be achieved in terms of inhalation flows. The presented algorithm can be used to develop a new computer based measurement system which could help to test and train patients' individual inhalation maneuvers with their inhalation devices." @default.
• W2493444967 created "2016-08-23" @default.
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• W2493444967 date "2016-09-01" @default.
• W2493444967 modified "2023-10-16" @default.
• W2493444967 title "Inhalation device requirements for patients' inhalation maneuvers" @default.
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• W2493444967 doi "https://doi.org/10.1016/j.rmed.2016.07.013" @default.
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• W2493444967 hasPublicationYear "2016" @default.
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